Given the significant impact of this disease, producers are continually looking for effective sanitation and water management practices that help reduce pathogen pressure in the production environment.
Evaluating Chlorine Dioxide Against aMPV-A
To better understand the antiviral effectiveness of chlorine dioxide, researchers conducted an in vitro study examining both activated and unactivated chlorine dioxide against aMPV-A.
In the study, aMPV-A was applied to tissue culture plates and exposed to various concentrations of chlorine dioxide for 10 minutes. Following treatment, researchers measured infectious viral titers using a Tissue Culture Infectious Dose Assay (TCID50) in Vero cells. Results were compared to the untreated virus control.3
Researchers observed a clear dose-response relationship, with higher chlorine dioxide concentrations producing greater reductions in aMPV-A infectivity under laboratory conditions. Compared to the untreated control, infectious virus levels were reduced by:
- 1.33 log at the 2:3 ppm treatment level
- 1.55 log at the 8:7 ppm treatment level
- 2.67 log at the 15:15 ppm treatment level
- More than 3.0 log at the 400:100 ppm treatment level
- 2.33 log at the 1000:0 ppm treatment level
The greatest reduction in infectivity was observed when activated chlorine dioxide was included at higher concentrations. However, unactivated chlorine dioxide alone also demonstrated measurable virucidal activity.3
What These Findings Mean for Poultry Producers
The results of this in vitro study demonstrated that chlorine dioxide can significantly reduce the infectivity of aMPV-A, supporting its role as part of a comprehensive biosecurity and sanitation program. Maintaining clean water systems and effective sanitation practices is essential for reducing pathogen pressure and supporting flock health and performance.
These findings add to the growing body of research demonstrating the effectiveness of chlorine dioxide against poultry pathogens and reinforce its value within modern biosecurity programs. By supporting water quality and helping to limit pathogen transmission, chlorine dioxide can be a valuable tool for poultry producers focused on protecting bird health, improving production outcomes, and strengthening overall flock health management.
PRO-OXINE® AH is a stabilized chlorine dioxide antimicrobial designed to disinfect animal drinking water, equipment, and premises. To learn more about PRO-OXINE AH from Kemin, visit kemin.com/prooxine.
References
1Rautenschlein, S., & Swayne, D. (2024). Avian Metapneumovirus Infection. Merck Veterinary Manual.
2Decision Innovation Solutions, Minnesota Turkey Growers Association, & Minnesota Corn Growers Association. (2025). The Economic Impact of aMPV on the Minnesota Turkey Industry.
3Kemin Industries. (2026). Effect of Unactivated and Activated Chlorine Dioxide on Avian Metapneumovirus Infectivity In Vitro (PTP-17888).
aMPV data are based on laboratory research and do not constitute an EPA-approved claim. Use products as directed on the EPA-approved label.
