ButiPEARL^® Z

Optimal Delivery of Butyric Acid and Zinc Benefits for Gut Health of Swine and Poultry

Butyric acid and zinc play an important role in key biological processes affecting the health and performance of production animals. Research indicates butyric acid and zinc are necessary to maintain the structural integrity of swine and poultry GI tract and key in creating a microflora balance. Encapsulating the nutrients ensures delivery all along the intestinal tract to the epithelial cells and tight junction proteins. In addition to the nutritional benefits, encapsulation provides superior handling by reducing the odor associated with butyric acid.

Take a closer look at our proprietary MicroPEARLS™ technology by watching the following video.

Butyric Acid

Butyric acid is an integral short-chain fatty acid acting as an energy source for epithelial cells. Butyric acid improves gut health through development of the intestinal epithelium. Benefits of butyric acid for broilers and swine include the upregulation of the expression of tight junction proteins in the intestines^1,2 and increases antioxidant levels to promote healing in the GI tract.² Butyric acid increases epithelial proliferation³ and host defense peptides,⁴ while also reducing inflammation.⁴

Zinc

Zinc benefits swine and poultry as an essential nutrient with a pivotal role in many key biological processes affecting the health and performance of livestock. Zinc serves as a structural role in DNA replication⁵ and aids in T-cell development.⁶ It is a cofactor for metabolic enzymes,⁷ wound healing enzymes⁸ and antioxidants.⁹ Zinc increases the microbial diversity in the intestines¹⁰ and similar to butyric acid, it upregulates the expression of tight junction proteins.¹¹

Inclusion of ButiPEARL Z in the diets of swine and poultry can positively impact the intestinal barrier focusing on the tight junctions. By upregulating the tight junctions, ButiPEARL Z can help increase the force exerted between the epithelial cells and minimize permeability, thus reducing the incidence of leaky gut.

Kemin Triple Check

The Kemin Triple Check product portfolio helps establish intestinal integrity and protection. Kemin offers products to CLEAN UP contaminants in feed and water prior to animal exposure, BUILD UP intestinal strength and immunity to reduce leaky gut and KNOCK OUT harmful pathogens for healthier and better performing poultry.

ButiPEARL^® Z was developed for the BUILD UP category by strengthening the intestinal barrier and immune system to maximize nutrient absorption and inhibit harmful pathogens or toxins.

Resources

References

¹Peng, L., et al. 2009. Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly via Activation of AMP-Activated Protein Kinase in Caco-2 Cell Monolayers. J. Nutr. 139:1619-1625.
²Ma, X., et al. 2012. Butyrate promotes the recovering of intestinal wound healing through its positive effect on the tight junctions. J. Anim. Sci. 90:266-268.
³Kotunia, A., et al. 2004. Effect of sodium butyrate on the small intestine development in neonatal piglets fed by artificial sow. J. Physiol. Pharmacol. 55:59-68.
⁴Guilloteau, P., et al. 2012. From the gut to the peripheral tissues: The multiple effects of butyrate. Nutr. Res. Rev. 23:366-384.
⁵Stefanidou, M., et al. 2006. Zinc: A multipurpose trace element. Arch. Toxicol. 80:1-9.
⁶Wellinghausen, N., et al. 1998. The significance of zinc for leukocyte biology. J. Leukoc. Biol. 64:571-577.
⁷McKall, K. A., et al. 2000. Function and Mechanism of Zinc Metalloenzymes. J. Nutr. 130:1437S-1446S.
⁸Lansdown, A. B. G., et al. 2007. Zinc in wound healing: Theoretical, experimental, and clinical aspects. Wound Rep. Reg. 15:2-16.
⁹Sahin, K., et al. 2009. Role of dietary zinc in heat-stressed poultry: A review. Poult. Sci. 88:2176-2183.
¹⁰Katouli, M., et al. 1999. The effect of zinc oxide supplementation on the stability of the intestinal flora with special reference to composition of coliforms in weaned pigs. J. of Applied Microbiology. 87:564-573.
¹¹Zhang, B., et al. 2012. Zinc prevents Salmonella enterica serovar Typhimurium-induced loss of intestinal mucosal barrier of function in broiler chickens. Avian Pathology. 41:361-367.

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