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Active Microbial for Swine: Knock Out Pathogenic Bacteria for Improved Gut Health

CLOSTAT® contains a unique, proprietary spore-forming strain of Bacillus subtilis, PB6 that attacks and kills clostridia and other pathogenic bacteria which can negatively impact the gastrointestinal (GI) tract. Because PB6 is a spore forming bacteria, it is compatible with most other ingredients and is able to survive harsh conditions, such as the acidity of the stomach or the temperatures associated with pelleting. With multiple product delivery options, CLOSTAT is the industry leader in reducing intestinal pathogen colonization leading to sickness in pigs. 

How CLOSTAT Works 

CLOSTAT One Pager - Monogastric

CLOSTAT® Use in Swine

There are two species of pathogenic Clostridium  bacteria associated with enteric disease in farrowing house piglets, Clostridium perfringens and Clostridium difficile. Bacillus subtilis PB6, the active ingredient in CLOSTAT®, has been shown via in vitro testing to inhibit the growth of these two Clostridium species. Hanson et. al demonstrated that the application of Bacillus subtilis PB6 during gestation and lactation to sows and post-farrowing to piglets had a positive effect on piglet performance during the pre-weaning period.1



Inclusion Level

CLOSTAT® Concentrate

For use in vitamin or trace mineral premixes

1.5 g / finished ton of feed


For use in vitamin or trace mineral premixes or feed mills capable of small quantity additions through micro machines

25 g / finished ton of feed


For use in feed mills

1 lb / finished ton of feed


Suitable for organic production use via delivery through feed

1 lb / finished ton of feed


Product Specifications

CLOSTAT Dry Spec Sheet
CLOSTAT 500 Spec Sheet
CLOSTAT Concentrate Spec Sheet
CLOSTAT Green Spec Sheet

Kemin Gut Health Triple Check

The Kemin Gut Health Triple Check program helps establish intestinal integrity and protection. Kemin offers products to CLEAN UP contaminants in feed and water prior to animal exposure, BUILD UP intestinal strength and immunity to reduce leaky gut and KNOCK OUT harmful pathogens for healthier and better performing poultry.

CLOSTAT® was developed for the KNOCK OUT category by supporting intestinal balance to inhibit or eliminate harmful pathogens from infiltrating the body.


Effect on Fecal Bacteriology and Sow He...



1Hanson J, Harms P, Culbertson M, et al.  Utilization of a direct-fed microbial (Bacillus subtilis, PB6) to improve performance of nursing piglets: Comparison of sow, piglet, and combination treatment regimens.  American Association of Swine Veterinarians 2009, pg 301-304.

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