You are viewing United States


Active Microbial for Beef and Dairy Cattle

The Problem is In the Gut   

Every day, through their environment, animals are exposed to pathogens, including Clostridia, Salmonella and E. coli. This exposure can impact the microbiota of the gastrointestinal tract.

Stress + Pathogenic Bacteria = Gut Health Challenge

Under stress events, both the mucosal layer and the tight junctions are negatively impacted, often leading to inflammation and reduced integrity of the intestinal barrier.

CLOSTAT for Ruminants Brochure


To optimize animal health, performance and profitability, you must optimize intestinal health.

CLOSTAT® contains a unique, proprietary spore-forming strain of Bacillus subtilis PB6. With a known mode of action, and over 15 years of research in livestock and poultry across the globe, PB6 has proven efficacy against Clostridia and other pathogenic species.1




Gut health beyond the rumen: Why the GI tract should be a core focus of your herd's health


Understanding how the gastrointestinal (GI) tract functions, how it contributes to overall ruminant health and what to do when it's compromised are critical to the success of your herd.

CLOSTAT for Ruminants Mode of Action
CLOSTAT for Ruminants One Pager
Effects of Feeding Bacillus Subtilis PB...
Evaluation of Bacillus subtilis PB6 to ...
The Inhibitory Effect of Bacillus subti...
CLOSTAT 500 Research in Large-Pen, Comm...


CLOSTAT® Mode of Action

The PB6 in CLOSTAT® has been found to secrete one or more biocidal proteins that are inhibitory towards certain strains of pathologenic bacteria such as Clostridium perfringens and other ruminant-specific pathogens.

The Impact of Clostridia and Salmonella on Ruminant Health

Dr. Rand Broadway

Dr. Rand Broadway is a research scientist with the USDA-ARS, Livestock Issues Research Unit in Lubbock, Texas. His program currently focuses on non-pharmaceutical supplements to mitigate the negative effects of diseases such as salmonellosis and Bovine Respiratory Disease. Simultaneously, his research aims to identify pathogenic colonization, migration and translocation patterns to enhance food safety, growth and carcass performance. Dr. Broadway received a B.S. in Biochemistry and a M.S. in Food Science and Technology from Mississippi State University. He received his Ph.D. from the Department of Animal and Food Sciences at Texas Tech University. 

My Calves and Heifers "Look Good," What Does that Really Mean?

Dr. Michael A. Ballou

Dr. Mike Ballou is an Associate Dean for Research, an Associate Professor of Nutritional Immunology in the College of Agricultural Sciences and Natural Resources and the interim chair for the Department of Veterinary Sciences at Texas Tech University. The focus of his research is to determine how nutrition and management influence the health and performance of dairy calves, heifers and periparturient cows. Dr. Ballou received a B.S. in Animal Science from the University of California, Davis, where he remained to complete a Ph.D. in Nutritional Biology with an emphasis in Immunology. In his presentation, "My Calves and Heifers 'Look Good,' What Does that Really Mean?", Dr. Ballou will discuss how we monitor and record benchmarks for herd success and how we use those benchmarks to adjust management strategy.

Cattle Health: It's Complicated!

Dr. Jeff Carroll

Dr. Carroll is a Research Physiologist and Research Leader for the USDA-ARS Livestock Issues Research Unit in Lubbock, Texas, where he leads a team working to develop management practices and alternative production systems to enhance animal wellbeing. In addition, his team is actively addressing methods to mitigate adverse effects of stress and develop alternatives to antimicrobials to enhance health and wellbeing of growing pigs and calves. Dr. Carroll completed his B.S. in Animal Science and his M.S. and Ph.D. in Physiology of Reproduction from Texas A&M University. In his presentation, "Cattle Health: It's Complicated," Dr. Carroll will challenge our thinking on current management practices and review potential alternative ways of managing cattle.



1United States Patent 7 ,247 ,299. Lin, et al. 2007.

Have a Question?

If you have a question about our products or services, or just want more information, fill out the form below and someone on our team will be in contact with you.