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Leaky Gut Syndrome and Chronic Diarrhea

Chronic diarrhea is more than just a nuisance. Nutrient and water absorption is decreased, your horse can become dehydrated and a variety of skin issues and irritations can occur. Quite often it's difficult or impossible to identify the root cause of chronic diarrhea, and some horses may suffer for months. In adult horses, this condition is almost always associated with damage and inflammation in the lining of the large intestine.1 If you repair the damage and reduce the inflammation, you may be able to reduce or eliminate the diarrhea.

Why Butyric Acid and Zinc?

Butyric acid (or butyrate) and zinc are two important nutrients that play a vital role in gut health. When delivered deep into the gut, they can help repair damage and reduce the inflammation of the lining of the large intestine.

Butyric Acid Functions:

  • Strengthen tight junctions2,3
  • Provide an energy source used in the growth and development of the intestinal lining4
  • Support immune function5
  • Reduce gut inflammation5

Zinc Functions:

  • Strengthen tight junctions6
  • Expedite wound healing7

Why ButiPEARL™ Z EQ?

The unique encapsulation technology of ButiPEARL™ Z EQ ensures the butyric acid and zinc are released slowly throughout the entire intestinal tract of the horse. Through this timely release process, the tight junctions are coated and strengthened – improving the integrity of the intestinal lining.

Where Can I Get ButiPEARL Z EQ?

Click here to find out if your feed contains ButiPEARL Z EQ.

ButiPEARL Z EQ One Pager



1Valle, E., Gandini, M., & Bergero, D. (2013). Management of Chronic Diarrhea in an Adult Horse. Journal of Equine Veterinary Science, 33(2), 130-135. doi:10.1016/j.jevs.2012.05.061
2Peng L, et al. Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly via Activation of AMP-Activated Protein Kinase in Caco.
3Cell Monolayers. 2009. J. Nutr. 139: 1619-1625; 2. Ma X, et al. Butyrate promotes the recovering of intestinal wound healing through its positive effect on the tight junctions. J Anim Sci. 2012. 90: 266–268.
4Kotunia A, et al. Effect of sodium butyrate on the small intestine development in neonatal piglets fed by artificial sow. J Physiol Pharmacol. 2004. 55: 59–68.
5Guilloteau P, et al. From the gut to the peripheral tissues: the multiple effects of butyrate. 2012 Nutr Res Rev. 23:366–384.
6Zhang B, et al. Zinc prevents Salmonella enterica serovar Typhimurium-induced loss of intestinal mucosal barrier function in broiler chickens. 2012. Avian Pathology. 41: 361–367.
7Lansdown ABG, et al. Zinc in wound healing: Theoretical, experimental, and clinical aspects. 2007. Wound Rep Reg 15:2–16.

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