Leaky Gut Syndrome and Chronic Diarrhea

Chronic diarrhea is more than just a nuisance. Nutrient and water absorption is decreased, your horse can become dehydrated and a variety of skin issues and irritations can occur. Quite often it's difficult or impossible to identify the root cause of chronic diarrhea, and some horses may suffer for months. In adult horses, this condition is almost always associated with damage and inflammation in the lining of the large intestine.1 If you repair the damage and reduce the inflammation, you may be able to reduce or eliminate the diarrhea.

References

¹Valle, E., Gandini, M., & Bergero, D. (2013). Management of Chronic Diarrhea in an Adult Horse. Journal of Equine Veterinary Science, 33(2), 130-135. doi:10.1016/j.jevs.2012.05.061
²Peng L, et al. Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly via Activation of AMP-Activated Protein Kinase in Caco.
³Cell Monolayers. 2009. J. Nutr. 139: 1619-1625; 2. Ma X, et al. Butyrate promotes the recovering of intestinal wound healing through its positive effect on the tight junctions. J Anim Sci. 2012. 90: 266–268.
⁴Kotunia A, et al. Effect of sodium butyrate on the small intestine development in neonatal piglets fed by artificial sow. J Physiol Pharmacol. 2004. 55: 59–68.
⁵Guilloteau P, et al. From the gut to the peripheral tissues: the multiple effects of butyrate. 2012 Nutr Res Rev. 23:366–384.
⁶Zhang B, et al. Zinc prevents Salmonella enterica serovar Typhimurium-induced loss of intestinal mucosal barrier function in broiler chickens. 2012. Avian Pathology. 41: 361–367.
⁷Lansdown ABG, et al. Zinc in wound healing: Theoretical, experimental, and clinical aspects. 2007. Wound Rep Reg 15:2–16.

Have a Question?

If you have a question about our products or services, or just want more information, fill out the form below and someone on our team will be in contact with you.