Europe CLOSTAT® and Antimicrobial Reduction

What happened after the banning of antimicrobial growth promoters  (AGP) in EU?

  1. Several monitoring systems were developed in different countries, for example:
  • In Sweden, the Swedish Veterinary Antimicrobial Resistance Monitorin (SVARM) system was established in 2000 (even though Swedish officials had been collecting data on antimicrobial use since 1980.
  • In Denmark, the Danish Integrated Antimicrobial Resistance Monitoring and Research Programme (DANMAP) was established and three years later a similar monitoring system was implemented for humans.
  • In The Netherlands, the Monitoring of Antimicrobial Resistance and Antibiotic Usage in Animals in MARAN was created as their monitoring system.
  1. In the United Kingdom, the government organized support for farmers in order to implement as best as possible the reduction of antibiotics in feed; nonetheless, the use of macrolides increased also in this area.
  1. In poultry production, there was a reduction of 90% in antimicrobial use in feed from 1995 to 2008.
  1. However, the therapeutic use of antibiotics increased, due to the need to treat infectious diseases like haemorrhagic enteropathy in pigs and cholangiohepatitis in broilers, to balance feed quality in broiler production, and to get non-specific conditions, such as dysbacteriosis, under control.
  1. European farmers recognized that management is crucial, consequently, guidelines were created, covering medication in farms, management and hygiene practices to keep animals healthy by preventing infections and recovering the loss in performance.

Status Of Antibiotics In EU 

Chickens on a farm

The use of antibiotics via water in the EU remains, and multidrug-resistant bacteria continue to spread among food animals.

Government Trend Against Antimicrobial Use

  • Following pressure from different consumer groups several governments requested a strong reduction in water medication. In 2013 some countries in North Africa also instituted a ban on AGP.

Other Solutions?

  • Finding replacements for AGPs in the EU has evolved into the use of different products, each with some of the benefits of AGP. 
  • Efficient management practices also play a key role in maintaining animal productivity in the absence of AGP. 
  • Producers continue to seek the ideal solution, but they know that it is unlikely that a single approach will ever be 100% efficient.

Existent Strategies

It seems inevitable that the use of AGP worldwide will decline in the future.  Where legislation is not already in place, consumer pressure is building up to make the practice of using antimicrobials economically impractical because of market limitations and export restrictions.  In general, an adequate vaccination program and a nutrition-based health strategy need to be developed to protect the animals from both infectious and non-infectious diseases. 

CLOSTAT As A Natural Solution

In 2010, an association of French veterinarians showed interest in CLOSTAT (water soluble). The objective of the trial was to examine if CLOSTAT could control or reduce bacterial enteritis and consequently decrease the use of antibiotics in the flocks.

The trial consisted of 11 farms, including 24 houses (11 control houses and 13 trial houses) with more than 600.000 broilers. 





Number of broilers




FCR (feed Kg: gain Kg)




Average age in days to market




Average slaughter weight (Kg)




Results in € / m²



+ 0.5

Relative medication cost / bird (€)




The trial resulted in a reduction in medication cost by half (-50%), an improvement of FCR by 0.06 (6 points) and an overall profit for the farmer of 0.5 € per square meter surface in the houses.

Certain statements may not be applicable in all geographical regions. Product labeling and associated claims may differ based upon government requirements.

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