CholiGEM™

At Kemin, we understand the critical role of the transition phase in setting the foundation for healthy animals and profitable dairy businesses. We strive to leverage the benefits of choline to turn challenges into opportunities for optimal ruminant nutrition.

Kemin’s scientists have invested more than half a decade in designing a unique “C3 Model” to achieve the best results from supplementing choline in our next-generation encapsulated choline solution — CholiGEM™.

Features and Benefits

• 60% Choline Chloride Concentration – A high-concentration product for maximum impact.
• Triple Bioavailability – Delivers more choline where it’s needed most: the intestine.
• Optimized Liver Function – Helps prevent fatty liver and ketosis to support energy and productivity.
• More Space in Premixes – Efficient formulation allows flexibility and cost savings in ration design.
• Proven Performance, Backed by Research – Developed with Kemin’s proprietary C3 Model and Choline Core Technology.

Our Unique C3 Model for Ruminant Nutrition

At Kemin, we have developed a unique C3 Model that ensures superior results from choline supplementation in dairy cows. Our next generation of encapsulated choline — CholiGEM™ — is an innovation in choline nutrition, raising the bar for higher performance in ruminant animals.

With superior bioavailability and an environmentally responsible green footprint, CholiGEM™ provides flexibility of application and multiple on-farm benefits.

The uniqueness of the C3 Model lies in:

• Choline Core Development – Designed for optimal coating using precision-engineered ingredients.
• Scientific Coating – A perfect balance of strength and release; not too strong to hinder choline release, and not too weak to break down in the rumen — achieving excellent results with 60% choline chloride.

Why Choline Nutrition Matters During the Transition Phase

The transition period — three weeks before and up to three weeks after calving — is one of the most critical phases in a dairy cow’s lifecycle. During this time, cows experience a severe Negative Energy Balance (NEB) as the energy demand for milk production exceeds feed intake.

To meet this energy gap, body fat is mobilized and transported to the liver — a condition known as hepatic lipidosis. Hepatic lipidosis is highly prevalent in dairy cows, affecting 50–60% of transition cows in the first three weeks postpartum (Bobe et al., 2004).

When the liver cannot efficiently process these fats into VLDL (Very Low-Density Lipoproteins), fat begins to accumulate, resulting in fatty liver and ketosis. Studies (Arshad et al.) have shown that when the level of triacylglycerol in the liver increases, cows are more prone to post-calving metabolic and health challenges.

The Role of Choline

Choline plays a vital role in:

• Phosphatidylcholine synthesis, essential for cell membrane structure and VLDL formation.
• Fat metabolism, ensuring mobilized fats are efficiently exported from the liver.
• Reducing metabolic disorders such as fatty liver and ketosis.

However, unprotected choline is rapidly degraded in the rumen and thus ineffective. The only reliable way to increase choline availability is by feeding rumen-protected choline (RPC), which ensures delivery to the small intestine for absorption and utilization.

CholiGEM™ & its Precision Design

Every aspect of CholiGEM™ — from its concentrated Choline Core to its innovative coating — has been developed with performance in mind.

CholiGEM™ offers a stable 60% choline concentration, along with consistent particle size, specific gravity, and improved handling characteristics. These features contribute to reduced microbial degradation, enhanced intestinal digestibility, and improved delivery of choline in dairy applications.

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