Tiza CURB®

Tiza CURB® is an advanced, bio‑active rumen optimizer designed for high‑producing dairy animals fed high‑concentrate diets, powered by M‑SAFE Technology. Tiza CURB® delivers prolonged rumen pH stability, supports rumen epithelial integrity, and actively promotes beneficial ruminal microflora, helping animals maintain performance under high SARA pressure. 

What is SARA

Subacute Ruminal Acidosis (SARA) is a subclinical but economically significant digestive disorder characterized by repeated drops in rumen pH (5.2–5.8) for 3–5 hours per day, without obvious clinical signs. The problem is called “subacute” because it is not as dramatic as acute acidosis, yet it is still serious enough to disturb rumen fermentation, upset microbial balance, and reduce digestive efficiency. 

The consequences of SARA can be both immediate and long-lasting. Inside the rumen, low pH reduces fiber digestion and changes the normal fermentation pattern, which means the animal gets less value from the ration. Outside the rumen, the effects start to show up in everyday performance: inconsistent feed intake, less cud chewing, loose manure, milk fat depression, poor body condition, and lower production efficiency.

One of the most important — and often overlooked — consequences of SARA is the release of lipopolysaccharides (LPS). In more persistent cases, the rumen lining becomes irritated and inflamed, leading to rumenitis. Once that protective lining is compromised, harmful compounds and bacteria can enter the bloodstream and contribute to liver abscesses, laminitis, and broader inflammatory stress. Which ultimately reduces feed efficiency, milk fat stability, and overall resilience of the animal

Why Traditional SARA Solutions Are Not Enough

Most conventional SARA management focuses primarily on pH buffering.

While buffering is important, pH correction alone does not:

• Restore damaged rumen epithelium 

• Reduce endotoxin‑driven inflammation

• Rebuild disrupted rumen microflora

What are LPS

LPS are endotoxins that form part of the outer membrane of Gram-negative bacteria. Under normal rumen conditions, they are present at low, controlled levels. During SARA, however, acid stress causes large‑scale death of Gram‑negative bacteria, releasing excessive amounts of free LPS into the rumen fluid. 

M‑SAFE Technology

M‑SAFE Technology is developed in response to this evolving understanding. Rather than focusing on a single symptom, M‑SAFE™ addresses the three fundamental dimensions of SARA disruption—chemical, structural, and biological. M‑SAFE is a multi‑shield technology designed to simultaneously address three dimensions of SARA disruption:

Chemical Shield – Prolonged pH Stabilization

The first shield of M‑SAFE focuses on maintaining rumen pH above the critical SARA threshold throughout the entire fermentation cycle. M‑SAFE achieves this through a multi‑phase buffering system, combining ingredients with different onset times.

Structural Shield– Rumen Wall & Inflammation Support

The second shield addresses one of the most critical yet under‑managed aspects of SARA. It works at the molecular level to address the downstream consequences of SARA — endotoxin (LPS) translocation, rumen epithelial damage, and systemic inflammation.

Biological Shield – Microbiome Rebalancing

The third shield of M‑SAFE focuses on restoring rumen microbial stability, which is often slow to recover even after pH normalizes. This shield of M‑SAFE actively rebuilds the rumen ecosystem disrupted by SARA. 

Tiza CURB®, powered by M‑SAFE technology, addresses the complexity of SARA through pH stabilization, rumen wall protection, immune modulation, and microbiome restoration — helping animals maintain performance, resilience, and long‑term productivity in modern high‑energy feeding systems. Tiza CURB® helps the animal respond more efficiently to LPS pressure, reducing the metabolic cost of chronic inflammation and improving resilience. It addresses downstream consequences of SARA by

• Supporting rumen epithelial integrity
• Helping modulate excessive inflammatory signaling
• Supporting immune resilience without over‑activation

To address the disrupted microbial system by SARA, Tiza CURB® also includes probiotics that support beneficial microbial populations and clinoptilolite – a natural aluminosilicate acting as a molecular sieve and supporting endotoxin management. 

Key Benefits of Tiza CURB®

• Prolonged rumen pH stability under high acid load
• Supports rumen lining health and inflammation control
• Actively promotes beneficial ruminal microflora growth
• Improves fermentation efficiency and fiber digestion
• Supports consistent feed intake and feed utilization
• Helps protect milk fat and sustain production under SARA pressure

Proven Under Field Conditions

Field evaluations across multiple locations and species have demonstrated improvements in:

• Average daily milk yield
• Feed conversion efficiency
• Performance consistency during trial periods compared with control or standard buffering strategies.

(Detailed trial data available on request or via technical support.)

Conclusion

SARA is not just a temporary drop in rumen pH. It is a whole‑rumen health and inflammatory challenge involving fermentation stress, endotoxin release, epithelial damage, and systemic consequences. Conventional buffering strategies may temporarily raise pH, but Tiza CURB® with M‑SAFE Technology is designed to deliver, in addition to that, to adequately address endotoxin pressure, epithelial injury, or microbiome imbalance. 

References

1.      Plaizier JC, Krause DO, Gozho GN, McBride BW. Subacute ruminal acidosis in dairy cows: The physiological causes, incidence and consequences. The Veterinary Journal. 2008;176:21-31.

2.      Li S, Gozho GN, Gakhar N, Khafipour E, Krause DO, Plaizier JC. Evaluation of diagnostic measures for subacute ruminal acidosis in dairy cows. Canadian Journal of Animal Science. 2012;92:353-364.

3.    Hou G, You J, Zhuang Y, Gao D, Xu Y, Jiang W, Li S, Zhao X, Chen T, Zhang S, Liu S, Wang W, Li S, Cao Z. Disorders of acid-base balance promote rumen lipopolysaccharide biosynthesis in dairy cows by modulating the microbiome. Frontiers in Microbiology. 2024;15:1492476.

4.      Bansod A, Khandare R, Shindhe B, Shelke V, Kurhe R, Namapalle M, Bashetti PN. A comprehensive review on sub-acute ruminal acidosis in dairy cow. International Journal of Advanced Biochemistry Research. 2024;8(2 Special Issue):529-536.

5.      Khafipour E, Li S, Plaizier JC, Krause DO. Rumen microbiome composition determined using two nutritional models of subacute ruminal acidosis. Applied and Environmental Microbiology. 2009;75(22):7115-7124.

6.      Enemark, Jörg & Jorgensen, Ross & Enemark, Peter. (2002). Rumen acidosis with special emphasis on diagnostic aspects of subclinical rumen acidosis: A review. Veterinarija Ir Zootechnika. 20. 16-29.

7.      Hou G, Wang J, Liu S, Gao D, Xu Y, Zhuang Y, Dong W, Yue Y, Bai J, Li S, Ma J, Li M, Wang W, Wang Y, Li S, Cao Z. Integrating Subacute Ruminal Acidosis, Lipopolysaccharide, and Trained Immunity: A Comprehensive Review. Int J Biol Sci. 2025 Mar 31;21(6):2806-2823. doi: 10.7150/ijbs.104074. PMID: 40303309; PMCID: PMC12035889. 

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