ButiPEARL™ is an encapsulated source of butyric acid manufactured using Kemin’s proprietary spray freezing process, named as MicroPEARLS. It allows slow and sustained release of butyric acid in the Intestinal tract.
Butyric acid is one of the short-chain fatty acids (SCFA) efficiently used & preferred source by the enterocytes of the gastrointestinal (GI) tract over glucose.
However, Butyric acid is a volatile and corrosive molecule characterized by a very unpleasant pungent odor, which restricts its processing in animal feed. In addition, it is rapidly absorbed by mucosal cells in upper part well before reaching small intestine. Thus different salts & coating of butyrate are used. These are soluble, generally more stable, less odorous, and easier to handle in the feed manufacturing process. Slower the solubility due to coating, better the efficacy of product.
1. Peng L, et al. Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly via Activation of AMP-Activated Protein Kinase in Caco-2 Cell Monolayers. J. Nutr.; Sep 2009; 139: 1619-1625.
2. Ma X, et al. Butyrate promotes the recovering of intestinal wound healing through its positive effect on the tight junctions. J Anim Sci.; Dec 2012; 90 Suppl 4: 266-268.
3. Kotunia A, et al. Effect of sodium butyrate on the small intestine development in neonatal piglets fed [correction of feed] by artificial sow. J Physiol Pharmacol. Jul 2004; 55 Suppl 2:59-68.
4. Guilloteau P, et al. From the gut to the peripheral tissues: the multiple effects of butyrate. Nutr Res Rev. 2010; 23:366–384.