ButiPEARL™ is an encapsulated source of butyric acid manufactured using a proprietary spray freezing process. MicroPEARLS® spray freezing technology allows for the slow release in the GI tract promoting an efficient use of butyric acid in swine and poultry. The encapsulation process greatly reduces the odor typically associated with butyric acid.
Butyric acid is one of the short-chain fatty acids (SCFA) most efficiently used by the epithelial cells of the gastrointestinal (GI) tract. Butyric acid promotes the growth of tissues lining the GI tract and development of the intestinal epithelium in monogastric animals.1,2
Cellular signaling to enterocytes1
Improves tight junctions in the intestines2
Increases antioxidant levels to promote healing in the GI tract2
Improves intestinal development3
Modulates immune response4
A fat matrix surrounds the butyric acid ensuring the MicroPEARLS is not digested immediately; it is the delivery system for the active material.
Particles of butyric acid salt are embedded in the MicroPEARLS matrix during the manufacturing process. Particles are released in the presence of an aqueous environment, leaving holes to new unexposed particles.
Liquid enters through exterior holes into the pearls and contacts the other particles of butyric acid. These particles are then released leaving new holes, as liquid contacts them. In the end, pearls look like empty shells.
The released material disassociates into butyric acid and calcium. The butyric acid can be absorbed by the epithelial cells of the intestinal tract. The calcium is also absorbed while the fat matrix is excreted.
1. Peng L, et al. Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly via Activation of AMP-Activated Protein Kinase in Caco-2 Cell Monolayers. J. Nutr.; Sep 2009; 139: 1619-1625.
2. Ma X, et al. Butyrate promotes the recovering of intestinal wound healing through its positive effect on the tight junctions. J Anim Sci.; Dec 2012; 90 Suppl 4: 266-268.
3. Kotunia A, et al. Effect of sodium butyrate on the small intestine development in neonatal piglets fed [correction of feed] by artificial sow. J Physiol Pharmacol. Jul 2004; 55 Suppl 2:59-68.
4. Guilloteau P, et al. From the gut to the peripheral tissues: the multiple effects of butyrate. Nutr Res Rev. 2010; 23:366–384.