LYSOFORTE™ Dry is the natural biological emulsifier that contains an optimized combination of Lysophospholipids, which plays a vital role in promoting more efficient utilization of dietary lipids and enhance the absorption of other nutrients.
Phospholipids and more particularly the lysophospholipids play an essential role in animal nutrition as biological emulsifiers and absorption enhancers. They improve the emulsification of feed fats and micelle formation; thereby enhancing the absorption of nutrients. Lysophospholipids are well known for enhancing nutrients absorption through increased membrane permeability of intestinal epithelial cells. Collectively this leads to a better feed utilization regarding energy, proteins, fats, and minerals and more environmentally friendly animal production.
The intestinal villi are covered with a single layer of absorptive and secretory cells in mammals. The more prominent collagen fibrils in the villi that we observed correspond to the lengthening of the villi.
LYSOFORTE™ Dry significantly increases the villi collagen fibers and the villi length in the jejunum. Longer villi would provide an improved absorptive area for the uptake of nutrients. An increase in tensile strength of the villi through increased deposition of collagen fibrils would enhance the overall structural health of the intestine.
Figure 1. Collagen visualization in jejunum sections (Control feed (left) versus Feed supplemented with LYSOFORTE™ Dry (right).
One of the critical factors affecting fat absorption is Critical Micellar Concentration (CMC). If the CMC drops, less fatty acids are needed to form a micelle, eventually leading to more fatty acids being absorbed by the animal. Lysophospholipids have a lower CMC and will dramatically improve fat and nutrient absorption.
Source: Zubay (1984) Table 1. The effect of various surfactants on Critical Micellar Concentration
By having smaller and more emulsion droplets, it would result in a lower critical concentration of fatty acids, leading to better fat absorption.
The benefits of LYSOFORTE™ Dry goes beyond better emulsion of fats. It has an extreme capacity to form smaller and more stable micelles in conjunction with fatty acids and other lipophilic molecules. The micelles that contain Lysophospholipids are better absorbed because these special molecules also can increase the cell membrane permeability of the intestinal epithelium cells to nutrients.
Figure 2. Micelle from Natural Bile (Left), Micelle from LYSOFORTE™ Dry (Right)
There are three applications of LYSOFORTE™ Dry in animal nutrition:
All feed fats follow the same digestive route, independently of whether they are added fats or are naturally present in feed components (e.g., oilseeds). LYSOFORTE™ Dry can improve digestibility of all feed fats.
AME matrix values for diets with different fats