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Digestive Aging™: The Quest to Keep the Gut Young at Heart

Are you a supplement manufacturer seeking to stay ahead in the competitive market of gut health solutions? Discover the key insights and innovative approaches that can set your products apart. Download our exclusive whitepaper, Digestive Aging™, and explore how Kemin's groundbreaking ingredients can elevate your offerings and meet the growing demand for effective digestive health solutions for aging populations.

What You'll Learn:

  • In-depth Analysis: Understand the unique challenges and needs of the aging digestive system.
  • Cutting-Edge Research: Gain insights from the latest scientific studies and research on gut health and aging.
  • Market Trends: Stay ahead of market trends and consumer expectations in the supplement industry.
  • Product Development Tips: Practical advice on formulating supplements that cater to the specific needs of aging adults.
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Discover Kemin's Innovative Digestive Aging Solutions

BetaVia™ provides a unique source of immune-boosting beta-glucans derived from algae. This ingredient not only supports digestive health but also enhances immune function, offering a dual benefit that is highly sought after in the supplement market.1-23

Harness the power of postbiotic Butyrate with ButiShield™. This innovative ingredient supports gut barrier integrity, immune function, and overall digestive health, making it a vital addition to supplements targeting aging populations.24-32





Certain statements may not be applicable in all geographical regions. Product labeling and associated claims may differ based upon government requirements.

These statements have not been evaluated by the US Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

The information on this webpage is a business-to-business information and not intended for the final consumer. Certain statements may not be applicable in all geographical regions. Product labeling and associated claims differs based upon government requirements and country or region specific information should also be considered when labeling or advertising to final consumers.

This web page and its associated brochures and other documents do not constitute or provide scientific or medical advice, diagnosis, or treatment and are distributed without warranty of any kind, either expressly or implied. This web page, its title or contents and associated brochures and other documents do not in any way make recommendations for health or marketing claims by the reader. Country and region specific regulations should be considered in this regard. Each claim or statement about the effectiveness of Kemin products and/or each claim or statement comparing the effectiveness of Kemin products to the effectiveness of other products is expressly limited to the United States, unless otherwise disclosed on the Kemin websites.


  1. Salminen, et al. Nat rev Gastroenterol Hepatol (2022).
  2. Evans, M., et al., Effect of a Euglena gracilis Fermentate on Immune Function in Healthy, Active Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.  Nutrients, 2019, 11(12), 2926
  3. Kemin, BetaVia Complete can prime key cells in the innate immune system. KHTL-017-150.
  4. KHTL-017-162 BetaVia Pure Can Prime Key Cell sin the Innate Immune system. KHTL-017-150.
  5. KHTL-017-160 Paramylon Improves Antioxidant Status and Metabolic Health-TL-20-18529
  6. KHTL-017-149 Characteristics and Prebiotic like Properties of BetaVia Complete
  7. Kemin, Characteristics and prebiotic like properties of BetaVia Complete. KHTL-017-149.
  8. Bhattad T, Koradiya A, Prakash G. Prebiotic activity of paramylon isolated from heterotrophically grown Euglena gracilis. Heliyon. 2022 Aug 27;7 (9): e07884. doi: 10.1016/j.heliyon.2022.e07884
  9. Russo, R., et al. “Euglena gracilis paramylon activates human lymphocytes by upregulating pro-inflammatory factors.” Food Science & Nutrition 5.2 (2017): 205-214
  10. Kondo, Y., et al. "Cytokine-related immunopotentiating activities of Paramylon, a β-(1→ 3)-D-glucan from Euglena gracilis." Journal of Pharmacobio-dynamics 15.11 (1992): 617-621.
  11. Kankkunen, P., et al. "(1, 3)-β-Glucans activate both dectin-1 and NLRP3 inflammasome in human macrophages." The Journal of Immunology 184.11 (2010): 6335-6342
  12. Brown, G.D., and Siamon G. Immune recognition: A new receptor for [beta]-glucans." Nature 413.6851 (2001): 36.
  13. Brown, G.D., et al. "Dectin-1 is a major β-glucan receptor on macrophages. Journal of Experimental Medicine 196.3 (2002): 407-412.
  14. Brown, G.D., et al. Dectin-1 mediates the biological effects of β-glucans." Journal of Experimental medicine 197.9 (2003): 1119-1124.
  15. Goodridge, H.S. et al. "β‐glucan recognition by the innate immune system. Immunological reviews 230.1 (2009): 38-50.
  16. KEMIN internal document: SD-18-00083
  17. Ishibashi, Ken-ichi, et al. “Effects of Euglena gracilis EOD-1 ingestion on salivary IgA reactivity and health-related quality of life in humans.” Nutrients 11.5 (2019): 1144.
  18. Nakashima, Ayaka, et al. “The alga Euglena gracilis stimulates Faecalibacterium in the gut and contributes to increased defecation.” Scientific reports 11.1 (2021): 1-8.
  19. Nakashima, Ayaka, et al. “Effects of Euglena gracilis Intake on Mood and Autonomic Activity under Mental Workload, and Subjective Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Trial.” Nutrients 12.11 (2020): 3243.
  20. Kawano, Takanori, et al. “Effect of Food Containing Paramylon Derived from Euglena gracilis EOD-1 on Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trail.” Nutrients 12.10 (2020): 3098.
  21. SD-17-00243 Kemin Internal Document (Effect of 50%BG on the immune and intestinal health status of weaned piglets)
  22. SD-9-21271 Kemin Internal Document (Effect of 50% BG on IgA in piglet feces)
  23. TD-17-0322 Kemin Internal Document (Effect of 50% and 95% BG on gut and systemic immunity in mice)
  24. Banasiewicz T, Domagalska D, Borycka-Kiciak K, Rydzewska G. Determination of butyric acid dosage based on clinical and experimental studies – a literature review. Gastroenterology Review/Przegląd Gastroenterologiczny. 2020;15(2):119-125. doi:10.5114/pg.2020.95556.
  25. Donohoe, D.R., Garge, N., Zhang, X., Sun, W., O'Connell, T.M., Bunger, M.K. and Bultman, S.J., 2011. The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Cell metabolism, 13(5), pp.517-526.
  26. Yan, H. and Ajuwon, K.M., 2017. Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway. PloS one12(6), p.e0179586.
  27. Peng, L., Li, Z.R., Green, R.S., Holzman, I.R. and Lin, J., 2009. Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers. The Journal of nutrition139(9), pp.1619-1625.
  28. Bach Knudsen, K.E., Lærke, H.N., Hedemann, M.S., Nielsen, T.S., Ingerslev, A.K., Gundelund Nielsen, D.S., Theil, P.K., Purup, S., Hald, S., Schioldan, A.G. and Marco, M.L., 2018. Impact of diet-modulated butyrate production on intestinal barrier function and inflammation. Nutrients, 10(10), p.1499.
  29. Facchin, S., Vitulo, N., Calgaro, M., Buda, A., Romualdi, C., Pohl, D., Perini, B., Lorenzon, G., Marinelli, C., D’Incà, R. and Sturniolo, G.C., 2020. Microbiota changes induced by microencapsulated sodium butyrate in patients with inflammatory bowel disease. Neurogastroenterology & Motility, 32(10), p.e13914.
  30. Gao, F., Lv, Y.W., Long, J., Chen, J.M., He, J.M., Ruan, X.Z. and Zhu, H.B., 2019. Butyrate improves the metabolic disorder and gut microbiome dysbiosis in mice induced by a high-fat diet. Frontiers in Pharmacology, 10, p.1040.
  31. Louis, P. and Flint, H.J., 2009. Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine. FEMS microbiology letters294(1), pp.1-8.
  32. Vital, M., Karch, A. and Pieper, D.H., 2017. Colonic butyrate-producing communities in humans: an overview using omics data. Msystems, 2(6), pp.e00130-17.
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