Slendesta® - A Hunger Control Supplement Ingredient

Sticking to a healthy diet and managing your weight isn’t easy. You've learned the hard way that weight loss won't happen overnight. In order to achieve long-term success, it's important to control your hunger and avoid binge eating. Slendesta is a dietary ingredient for satiety that offers the support dieters need to control hunger and feel full between meals.

When formulated into a supplement or food product, Slendesta helps:

  • Boost satiety to help you feel full sooner and longer.1
  • Suppress your appetite and control hunger, which makes dieting easier and helps with weight management.1
  • Promote weight loss and reduce waist and hip measurements when used with a sensible diet and exercise routine.2,3

How Slendesta Works:

 

Studied in 12 clinical trials – A safe and effective satiety solution

Slendesta is a safe, natural potato protein-based dietary supplement ingredient that boosts satiety to help you feel full, without any unpleasant side effects.4 The satiety ingredient has been studied in 12 clinical trials and when used with a sensible diet and exercise regimen, has been clinically shown to help individuals eat less and feel satisfied sooner and longer.1

The ingredient’s satiety benefits make it easier to control portion size and snacking, and in turn, achieve weight management goals.

Natural hunger control developed with advanced plant science

The active molecule in Slendesta is a well-studied protein called Proteinase Inhibitor II (PI2). PI2 works by promoting and extending the body’s natural release of cholecystokinin (CCK), a powerful peptide that signals key organs, including the stomach and brain, to induce feelings of fullness. To leverage the powerful satiety benefits of PI2, our plant scientists began searching for a natural source of this molecule.

We discovered russet potatoes have naturally occurring higher levels of PI2 and can serve as a botanical factory for our satiety ingredient.5 Kemin’s Specialty Crop Improvement (SCI) team used traditional plant breeding methods to further develop these potatoes.

Carefully grown and manufactured for weight management

Kemin’s potato supply chain is nearly 100% vertically integrated, allowing us to provide a safe and traceable satiety ingredient. We partner with farmers in the USA to grow and harvest our potatoes. From the fields, the potatoes are transported to Kemin’s state-of-the-art extraction facility in Des Moines, Iowa for storage and processing.

We use a patented water-based extraction process without harsh chemical solvents. The specialized extraction and ultra-filtration techniques do not alter PI2 functionality and allow us to standardize Slendesta to guaranteed levels of PI2. After the manufacturing process is complete, Slendesta is packaged at Kemin and prepared for shipment to customers worldwide.

Slendesta is manufactured in accordance with GMPs for food, 21 C.F.R. 110 and 117 by the U.S. Food and Drug Administration (FDA). Kemin Foods, L.C. facilities also conform to the NSF® International Dietary Supplement & Functional Foods Program-NSF/ANSI 173 Section 8 standard, which is based on 21 C.F.R. 111 Dietary Supplement GMPs.

Clinically-studied satiety and weight management benefits

The satiety and weight management benefits of Slendesta and PI2 have been clinically studied in 12 human clinical trials with more than 500 collective participants. Participants were told the benefits of a healthy diet and exercise, but were not prescribed a specific regimen. No adverse side effects were reported in any Slendesta clinical trial.

Increased feelings of fullness Demonstrated weight loss Decreased post-meal blood sugar

In a randomized, double-blind, placebo-controlled (RDBPC) study, healthy individuals took 300 mg or 600 mg of Slendesta 60 minutes before breakfast.

The group taking Slendesta reported significantly greater fullness levels and decreased motivation to eat compared to the placebo group.1 These subjective feelings of appetite were measured based on a Visual Analog Scale (VAS) rating.

Post-meal CCK satiety signal levels were significantly increased and remained elevated longer as compared to the placebo group.1 

In the largest RDBPC multi-site clinical study conducted with Slendesta, healthy overweight individuals who consumed Slendesta experienced statistically significant weight management benefits.2

The 12-week study showed Slendesta, when consumed 60 minutes before the two largest meals of the day, resulted in statistically significant reductions in weight, waist and hip measurements from baseline as compared to placebo.2

The maximum weight loss in this study was just over 20 pounds (9.3 kg) in the 600 mg group.2 87% of subjects reported satisfaction with Slendesta.

A published RDBPC crossover study with healthy overweight and obese individuals studied post-meal blood glucose levels.7

Blood sugar levels were measured pre-meal and at 36, 60, 90 and 120 minutes post-meal.

Individuals who consumed 300 mg Slendesta 30 minutes prior to meal showed a 25% overall decrease in blood glucose; and individuals who consumed 600 mg experienced a 20% decrease.Additional study results have shown significant decreases in blood sugar. 

Increased feelings of fullness

In a randomized, double-blind, placebo-controlled (RDBPC) study, healthy individuals took 300 mg or 600 mg of Slendesta 60 minutes before breakfast.

The group taking Slendesta reported significantly greater fullness levels and decreased motivation to eat compared to the placebo group.1 These subjective feelings of appetite were measured based on a Visual Analog Scale (VAS) rating.

Post-meal CCK satiety signal levels were significantly increased and remained elevated longer as compared to the placebo group.1 

Demonstrated weight loss

In the largest RDBPC multi-site clinical study conducted with Slendesta, healthy overweight individuals who consumed Slendesta experienced statistically significant weight management benefits.2

The 12-week study showed Slendesta, when consumed 60 minutes before the two largest meals of the day, resulted in statistically significant reductions in weight, waist and hip measurements from baseline as compared to placebo.2

The maximum weight loss in this study was just over 20 pounds (9.3 kg) in the 600 mg group.2 87% of subjects reported satisfaction with Slendesta.

Decreased post-meal blood sugar

A published RDBPC crossover study with healthy overweight and obese individuals studied post-meal blood glucose levels.7

Blood sugar levels were measured pre-meal and at 36, 60, 90 and 120 minutes post-meal.

Individuals who consumed 300 mg Slendesta 30 minutes prior to meal showed a 25% overall decrease in blood glucose; and individuals who consumed 600 mg experienced a 20% decrease.Additional study results have shown significant decreases in blood sugar. 

Slendesta: The safe dietary ingredient for satiety

Slendesta is generally recognized as safe (GRAS) and has been shown to be well tolerated in all human clinical trials with no adverse side effects related to the study product.1-6

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About Kemin

Kemin strives to improve the quality of life by touching half the people of the world every day with our products and services. We are committed to delivering safe, high-quality ingredients backed by science and clinical research.

 

1Dana, S. et. al. Slendesta potato extract promotes satiety in healthy human subjects: Iowa State University (ISU) study. Kemin Health Technical Literature KHBB-017-050, 2006.

2Dana, S. A randomized, double-blind, placebo-controlled clinical study demonstrates Slendesta Potato Protein Extract is a safe and effective tool for promoting weight reduction. Kemin Health Technical Literature KBB-017-044, 2006

3Dana, S. A 20-week open-label clinical study shows Slendesta Potato Protein Extract is effective for weight loss and improved body measurements. Kemin Health Technical Literature KHBB-017-045, 2006.

4The Kemin Foods, L.C. definition of a “natural” ingredient is an ingredient with the identical molecular structure and characteristics as found in nature. The ingredient is derived solely from a plant, animal or mined sources, either in an unprocessed state or having been subject to moderate processing (physical processing, heating processing, purification, hydrolysis, extraction, drying). The ingredient does not contain any additives, except in amounts that might occur unavoidably during good manufacturing practices or good farming practices as applicable.

5Holt et al., Eur J Clin Nutr. 49 (9): 675-90.

6Spreadbury D. et al. A proteinase inhibitor extract from potatoes reduces post-prandial blood glucose in human subjects. JANA 6: 29-38, 2003.

7Hu, J. et al. (2013). GRAS Status for Slendesta® Potato Extract. Kemin Health Technical Literature KHBB-017-071.

NSF® is a trademark of NSF International.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Certain statements may not be applicable in all geographical regions. Product labeling and associated claims may differ based upon governmental requirements.

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