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MEVAC™ ELI VAR 2

Product Overview

MEVAC™ ELI VAR 2 is a live-attenuated bivalent vaccine containing Infectious Bronchitis virus (VAR 2) and Newcastle Disease virus (GII VG/GA strain).

Target Species

Chickens.

Respiratory Integrity Poultry

Co-infections with Infectious Bronchitis and Newcastle Disease viruses

Respiratory diseases are among the most devastating challenges in the poultry industry; in most cases, these are the result of more than one pathogen involved. Among several avian viruses with tropism of the respiratory tract, Infectious Bronchitis virus (IBV) and Newcastle disease virus (NDV) are the most important agents compromising poultry health worldwide.1

Due to the single stranded nature of their genome, these two viruses are able to evolve rapidly, leading to high genetic variability in circulating virus strains. This is even more pronounced in the case of IB, where recombination contributes to genetic variation. IB and ND affect poultry birds of all ages and breeds, but the degree of disease varies based on the age of the birds, with IB being more severe in young chicks, while the severity of ND is more pronounced in chickens of all ages.2

The immunology of domestic birds has been well studied and numerous vaccines have been developed against the two viruses. Most of these vaccines are either inactivated vaccines or live attenuated vaccines. Inactivated vaccines typically induce weaker cellular immune responses and require priming with live vaccines.2

Using various strategies such as combination of live attenuated and inactivated vaccines or the development of combined IB/ND vaccines, will lead to effective programs that contribute to poultry health and food security in many countries on a global scale.2

Product Description

Composition

  • Newcastle Disease Virus, GII VG/GA [ME/NDV2] ≥6.0 log10 EID50/dose
  • Infectious Bronchitis Virus, GI-23 (variant-2) [Eg/1212B] ≥3.0 log10 EID50/dose.

Indications

Active immunization to reduce mortality and clinical signs associated with Newcastle Disease and Avian Infectious Bronchitis.

Vaccination Program

Birds can be vaccinated from first day of age onwards, as per advice from your poultry veterinarian.

Immunity

  • Onset of immunity: 2 weeks after primary vaccination.
  • Duration of immunity: until 6 weeks after single dose.

Vaccine Preparation

  • Vaccine shall be reconstituted with sterile water free from disinfectant and/or antiseptic.
  • Shake the reconstituted lyophilisate until complete resuspension before administration.
  • Do not administer less than the recommended dosage.
  • Read instructions for appropriate dilution.

Withdrawals

Zero days.

Administration

The vaccine should be administered via the eye drop, spray, or drinking water routes.

  • Eye drop: For 1,000 birds, reconstitute 1,000 doses into 3 to 5 ml of non-chlorinated drinking water and subsequently dilute it into 30-50 ml of non-chlorinated drinking water. Use a calibrated dropper to distribute 30-50 μl-drops. Place one drop of the vaccine solution on the eye of each bird, allow the drop to spread, and release the bird. 
  • Spray vaccination: For 1,000 birds, spray the vaccine solution above the birds using a spray capable of producing micro-droplets (mean diameter 80-100 μm). Make sure that birds are closely confined together during spraying. The ventilation system of the poultry house should be inoperative during the spray administration.
  • Drinking water: For 1,000 birds, reconstitute the lyophilisate pellet corresponding to 1,000 doses into 3 to 5 ml of non-chlorinated drinking water and subsequently dilute it into the volume of non-chlorinated drinking water to be consumed within two hours.

Storage Precautions

  • Store and transport refrigerated (+2°C to +8°C).
  • Do not freeze.
  • Store in a dry place protected from direct light.
  • Do not use this product after the expiry date.
  • Shelf life: 24 months after manufacturing date. 
  • Shelf life after reconstitution according to directions: 3 hours.
MEVAC™ ELI VAR 2

Presentation

MEVAC™ ELI VAR 2 is packed and presented in a cardboard box containing 10 glass vials of 6 mL, 8 mL, or 10 mL. Contents per vial: 500, 1,000, 2,500, or 5,000 doses. Not all pack sizes may be marketed.

Download the Product Information Sheet

MEVAC™ ELI VAR 2
Download

References

1. Malik YS, Patnayak DP, Goyal SM. Detection of three avian respiratory viruses by single-tube multiplex reverse transcription-polymerase chain reaction assay. J Vet Diagn Invest. 2004.

2. Ike et al 2021. Towards Improved Use of Vaccination in the Control of Infectious Bronchitis and Newcastle Disease in Poultry: Understanding the Immunological Mechanisms. Vaccines 2021, 9(1), 20; https://doi.org/10.3390/vaccines9010020

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The content on this site is intended for informational purposes only and is not intended to be a substitute for professional veterinary advice. Although the information on this site is accessible worldwide, not all products or services are available to all persons or in all geographic locations or jurisdictions. Certain statements, product labeling and claims may differ by geography or as required by local governmental regulations.