You are viewing South Asia


Product Overview

MEFLUVAC™ H5 PLUS 8 is an inactivated trivalent vaccine for immunization against Highly Pathogenic Avian Influenza (HPAI) H5 subtypes.

Target Species


Combating Highly Pathogenic Avian Influenza in commercial poultry

Highly pathogenic avian influenza (HPAI) is an extremely contagious, multi-organ systemic disease leading to high mortality in poultry.1 The disease is caused by some H5 and H7 subtypes of type A influenza virus, family Orthomyxoviridae.These HPAI viruses can develop from certain LPAI viruses, usually while they are circulating in poultry flocks.2

HPAI viruses can cause mortality in 90-100% of the flock, and trigger epidemics that may spread rapidly, devastate the poultry industry and result in severe trade restrictions. Use MEFLUVAC™ H5 PLUS 8 to help combat HPAI in your poultry operation.

Product Description

Composition (Before Inactivation)

  • Inactivated Avian Influenza H5N1 subtype, clade [A/Chicken/Egypt/ RG-173 CAL/2017(H5N1)] ≥ 8.5 log10 EID50 / dose.
  • Inactivated Avian Influenza H5N1 subtype, clade [RgA/CK/Egypt/ME1010/2016(H5N1)] ≥ 8.5 log10 EID50 / dose.
  • Inactivated Avian Influenza H5N8 subtype clade [rgA/chicken/ME-2018/H5N8] ≥ 8.5 log10 EID50 / dose.


For booster vaccination and protection of commercial poultry against Highly Pathogenic Avian Influenza H5N1 and H5N8 subtypes.

Vaccination Program

Birds can be vaccinated from seven days of age onwards, as per advice from your poultry veterinarian.  

  • Broilers and quails: apply single dose from the 1st until the 7th day of age. Booster dose may be required in case of high-risk seasons and areas.
  • Turkey and ducks: apply two successive full doses with 3-4 weeks intervals.
  • Layers, breeders and grandparent flocks: apply 3 to 4 successive doses. The 1st dose should be applied within the first 2 weeks of age, the 2nd dose 3-4 weeks later, the 3rd dose among 8-10 weeks of age and the 4th dose after having conducted the serological monitoring.


Zero days. 

Additional Features

  • High homology with field strains. 
  • Cross protection to H5N6 subtype.
  • Proven efficacy under field conditions. 
  • High antigenic mass. 
  • Significantly reduces virus shedding.


The vaccine dose (0.5 mL/bird) should be administered subcutaneously in the lower part of the neck or intramuscularly in the thigh or breast muscles.


Before use, the vaccine should be shaken well to ensure proper mixing. Sterile injection equipment should be used to avoid contamination. 

  • Subcutaneous injection: apply in the lower part of the neck. The needle should be inserted just under the skin in a direction away from the head and in a straight line with the neck.
  • Intramuscular injection: when applied in the breast muscles the needle must be inserted with a 45° angle to avoid intraperitoneal injection. 

Storage Precautions

  • Store and transport refrigerated (+2°C to +8°C).
  • Do not freeze.
  • Store in a dry place protected from direct sunlight.
  • Do not use this product after the expiry date.
  • Shelf life after first opening the bottle: 3 hours.


MEFLUVAC™ H5 PLUS 8 is packed and presented in 500 mL (1000 doses) polyethylene terephthalate (PET) bottles.

Download the Product Information Sheet



1. Swayne DE, Suarez DL. Highly pathogenic avian influenza. Rev Sci Tech. 2000 Aug;19(2):463-82. doi: 10.20506/rst.19.2.1230. PMID: 10935274.

2. The Center for Food Security and Public Health, November 2015, Avian Influenza Fowl Plague, Grippe Aviaire.

Start Vaccination against HPAI Clades Spreading Worldwide

Fill out the form below to connect with Kemin's vaccine experts.

The content on this site is intended for informational purposes only and is not intended to be a substitute for professional veterinary advice. Although the information on this site is accessible worldwide, not all products or services are available to all persons or in all geographic locations or jurisdictions. Certain statements, product labeling and claims may differ by geography or as required by local governmental regulations.