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Product Overview

MEVAC™ MULTI ADENO is an inactivated trivalent vaccine against Inclusion Body Hepatitis and Hydropericardium Hepatitis Syndrome.

Target Species


Immunocompetence Poultry

Fowl Adenoviruses in Poultry Populations

Fowl adenoviruses (FAdVs) are common pathogens of poultry, causing a variety of diseases such as inclusion body hepatitis (IBH), hydropericardium syndrome (HPS), and gizzard erosion. FAdVs are classified into five species (FAdV-A to FAdV-E) and more than 12 serotypes based on their hexon and fiber genes.1

FAdV-A and FAdV-C primarily cause respiratory diseases in poultry, while FAdV-D is associated with IBH, a severe liver disease characterized by the presence of eosinophilic intranuclear inclusion bodies in hepatocytes. IBH occurs in broiler and layer chickens, causing significant economic losses to the poultry industry worldwide.Clinical signs of IBH include anorexia, depression, increased thirst, yellow diarrhea, and increased mortality rates.1  Try MEVAC MULTI ADENO to combat the effects of IBH and HPS in your operation.

Product Details

Composition (Before Inactivation)

  • Inactivated Fowl adenovirus, species C, serotype 4 [ME/FAdV-4] ≥ 5.0 log10 TCID50/dose.
  • Inactivated Fowl adenovirus, species D, serotype 11 [F563] ≥ 5.0 log10 TCID50/dose.
  • Inactivated Fowl adenovirus, species E serotype 8 [F422] ≥ 5.0 log10 TCID50/dose.


For the immunization of chickens to protect against the clinical signs and mortality associated with inclusion body hepatitis and hydropericardium hepatitis syndrome.

Vaccination Program

Birds can be vaccinated from seven days of age onwards, as per advice from your poultry veterinarian.


Zero days.



  • The vaccine should not be used if chickens are diseased or immunosuppressed.
  • Do not mix with any other veterinary medicinal product.
  • No side-effect has been observed during the rearing period following administration of double the recommended dose of vaccine.
  • The safety of the veterinary medicinal product has not been established during lay.
  • Vaccine bottles shall be shaken well before use.
  • Use sterile injection equipment.

Vaccine Preparation

  • Vaccine shall be reconstituted with sterile water free from disinfectant and/or antiseptic.
  • Shake the reconstituted lyophilisate until complete resuspension before administration.
  • Do not administer less than the recommended dosage.
  • Read instructions for appropriate dilution.


The vaccine dose (0.5 mL/bird) should be administered subcutaneously in the lower part of the neck or intramuscularly in the thigh or breast muscles.


Before use, the vaccine should be shaken well to ensure proper mixing. Sterile injection equipment should be used to avoid contamination.

  • Subcutaneous injection: in the lower part of the neck. The needle should be inserted just under the skin in a direction away from the head and in a straight line with the neck.
  • Intramuscular injection: in the breast muscles by inserting the needle with a 45° angle to avoid intraperitoneal injection.

Storage Precautions

  • Store and transport refrigerated (+2°C to +8°C). 
  • Do not freeze.
  • Store in a dry place protected from direct sunlight.
  • Do not use this product after the expiry date.
  • Shelf life after first opening the bottle: 3 hours.


MEVAC™ MULTI ADENO is packed and presented in 500 mL (1000 doses) polyethylene terephthalate (PET) bottles.

Download the Product Information Sheet



1. Elena Mettifogo et al., Fowl adenovirus Group I as a causal agent of inclusion body hepatitis/hydropericardium syndrome (IBH/HPS) outbreak in brazilian broiler flocks,Livestock Diseases, 2014

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