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Product Overview

MEFLUVAC™ H5N8 is an inactivated monovalent vaccine for immunization against Highly Pathogenic Avian Influenza H5 subtype.

Target Species


Immunization against Highly Pathogenic Avian Influenza

Highly pathogenic avian influenza (HPAI) is an extremely contagious, multi-organ systemic disease leading to high mortality in poultry.The disease is caused by some H5 and H7 subtypes of type A influenza virus, family Orthomyxoviridae.1 These HPAI viruses can develop from certain LPAI viruses, usually while they are circulating in poultry flocks.2 HPAI viruses can cause mortality in 90-100% of the flock and trigger epidemics that may spread rapidly, devastate the poultry industry, and result in severe trade restrictions.2

Field results indicate that movement control, systematic surveillance for wild birds, serological monitoring in commercial poultry, complemented with biosecurity measures and vaccination, are crucial to mitigate the impact caused by HPAI strains.3

Product Details

Composition (Before Inactivation)

  • Inactivated reassortant Avian Influenza H5N8 subtype, clade [rgA/chicken/ME-2018/ H5N8] ≥ 8.5 log10 EID50 / dose.


For booster vaccination and protection of commercial poultry against Highly Pathogenic Avian Influenza H5N8 subtype.

Vaccination Program

Birds can be vaccinated from five days of age onwards, as per advice from your poultry veterinarian.

  • Broilers: apply single dose only. Booster dose may be required in case of high-risk seasons and areas.
  • Layers, breeders and grandparent flocks: apply 3 to 4 successive doses. The 1st dose should be applied within day 5 and 15 of age, the 2nd dose 3-4 weeks later, the 3rd dose after 8-10 weeks of age and the 4th dose after having conducted the serological monitoring.


Zero days.


  • High homology with field strain circulating globally
  • High antigenic mass
  • Significantly reduces virus shedding


The vaccine dose (0.5 mL/bird) should be administered subcutaneously in the lower part of the neck or intramuscularly in the thigh or breast muscles.


Before use, the vaccine should be shaken well to ensure proper mixing. Sterile injection equipment should be used to avoid contamination.

  • Subcutaneous injection: in the lower part of the neck. The needle should be inserted just under the skin in a direction away from the head and in a straight line with the neck.
  • Intramuscular injection: in the breast muscles by inserting the needle with a 45° angle to avoid intraperitoneal injection. 

Storage Precautions

  • Store and transport refrigerated (+2°C to +8°C). 
  • Do not freeze.
  • Store in a dry place protected from direct sunlight.
  • Do not use this product after the expiry date.
  • Shelf life after first opening the bottle: 3 hours.


MEFLUVAC™ H5N8 is packed and presented in 500 mL (1000 doses) polyethylene terephthalate (PET) bottles.

Download the Product Information Sheet



1. Swayne DE, Suarez DL. Highly pathogenic avian influenza. Rev Sci Tech. 2000 Aug;19(2):463-82. doi: 10.20506/rst.19.2.1230. PMID:10935274.

2. The Center for Food Security and Public Health, November 2015, Avian Influenza Fowl Plague, Grippe Aviaire.

3. EFSA and ECDC, along with other experts, published a report on avian influenza in March-April 2023. [EFSA J. 2023;21(6):e08039]

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