Natural Satiety Support for Fullness That Feels Right

Slendesta® is a clinically studied satiety ingredient derived from upcycled potatoes. It contains Proteinase Inhibitor II, also known as PI2, a protein that enhances the release of cholecystokinin (CCK) - a gut hormone that delays gastric emptying and helps signal fullness to the brain through the vagus nerve. 

Designed to work in harmony with the body’s natural appetite-control signals, Slendesta® provides a gentle, science-backed approach to supporting satiety, mindful eating, and weight-management goals without stimulants. 

Explore Slendesta® for your next satiety or weight-management formulation.

How does Slendesta® work?

Slendesta® works through the gut-brain axis - the communication pathway between the digestive system and the brain.

When food is eaten, the small intestine naturally releases CCK. This hormone signals the brain through the vagus nerve to promote feelings of fullness and helps regulate glucose levels after meals. CCK also works alongside other appetite-related hormones, including GLP-1, PYY, GIP*, and ghrelin. 

By enhancing this natural satiety response, Slendesta® helps support appetite control in a way that is gentle, non-stimulant, and aligned with the body’s own fullness signals. 

Why satiety matters

Satiety is the feeling of fullness after eating. Supporting satiety can help consumers manage hunger, reduce the desire to eat, and support healthier eating patterns.

As consumers look for weight-management solutions that feel natural, balanced, and sustainable, Slendesta® offers a science-backed ingredient that supports fullness without stimulants or extreme hunger suppression. 

Clinically supported benefits of Slendesta®

Slendesta® is supported by 21 human clinical studies exploring the effects of PI2 including more than 500 healthy participants. Data suggests that individuals who took 300-600mg of Slendesta 60 minutes before a meal found that 2-3 hours post meal, had reduced feelings of hunger, less desire to eat. 

A gentle, natural choice for weight-management innovation

Backed by science, Slendesta seamlessly integrates into any health journey by providing consumers with a natural approach that promotes sustainable changes in eating behaviors or as a support for their current regimens. 

Formulation opportunities

• Slendesta® is a versatile satiety ingredient for food, beverage, and supplement applications designed to support fullness, appetite control, mindful eating, and weight management.
• Potential applications include functional beverages, powder mixes, gummies, nutrition bars, weight-management supplements, healthy-aging products, active nutrition products, and sports nutrition products.
• Kemin’s Customer Laboratory Services team can support manufacturers in developing innovative formulations with Slendesta®.

Quick answers

Control Appetite, Naturally

Slendesta® supports the body’s natural satiety signals to help create fullness that feels right. For brands developing weight-management, satiety, or mindful-eating products, Slendesta® offers a natural, clinically studied, stimulant-free solution backed by human research.

Resources

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These statements have not been evaluated by the US Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

The information on this webpage is a business-to-business information and not intended for the final consumer. Certain statements may not be applicable in all geographical regions. Product labeling and associated claims differs based upon government requirements and country or region specific information should also be considered when labeling or advertising to final consumers.

This web page and its associated brochures and other documents do not constitute or provide scientific or medical advice, diagnosis, or treatment and are distributed without warranty of any kind, either expressly or implied. This web page, its title or contents and associated brochures and other documents do not in any way make recommendations for health or marketing claims by the reader. Country and region specific regulations should be considered in this regard. Each claim or statement about the effectiveness of Kemin products and/or each claim or statement comparing the effectiveness of Kemin products to the effectiveness of other products is expressly limited to the United States, unless otherwise disclosed on the Kemin websites.

References

1. Blundell, J. E. The control of appetite: basic concepts and practical implications. Schweiz Med Wochenschr 129, 182–8 (1999).

2. Zhu Y., et al. Food Funct. 2017 May 24;8(5):1988-1993

3. Spreadbury et al. 2003. JANA. 6(1): 29-38.​

4. Wochenschr 129, 182–8 (1999).

5. Rehfeld, J.F., 2025.. Peptides, 186, p.171369.
   
   *GLP-1 - Glucagon-like peptide-1; PYY – Peptide YY; GIP - Glucose-dependent insulinotropic polypeptide