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MEVAC™ MULTI IB+ND7

Product Overview

MEVAC™ MULTI IB+ND7 is an inactivated pentavalent vaccine containing IBV (Classic M41, GI-13 and GI-23 strains), and NDV GII, GVII strains.

Target Species

Chickens.

Respiratory Integrity Poultry

Co-infections with Infectious Bronchitis and Newcastle Disease viruses

The Infectious Bronchitis Virus (IBV) poses a significantthreat to the poultry industry due to its highly contagious nature and its capacity to cause acute infections in chickens.1,2

To combat IBV, vaccination stands as the key strategy. However, the global prevalence of both classical and variant IBVs, coupled with the limited efficacy of traditional Mass-type vaccines against multiple IBV variants, presents considerable challenges for effective control.3,4 These variants have been identified across various regions, such as: Latin America5, Africa6, Asia7, and Australia8. Understanding the genetic diversity of IBV has led to the classification of 32 lineages within 6 genotypes based on analysis of the S1 gene. While certain lineages like GI-1, GI-13, and GI-19 exhibit broad distribution, notably, the GI-23 lineage, initially confined to the Middle East, has now gained prominence and extends its presence to Europe, Asia, and Africa, indicating its expanding geographical influence over time.9

On the other hand, Newcastle Disease virus (NDV) remains endemic across many geographies worldwide. Antigenic similarity is found among all NDV genotypes, and all viruses are expected to cross-protect against challenge with each other. Thus, immunological stimulation can serve as a basis for vaccination with low virulence NDV vaccines to protect against virulent NDV (vNDV).10

Product Description

Composition (before inactivation)

  • Inactivated Avian Infectious Bronchitis Virus, GI-1 lineage (classic) [IBV-EG/M41-ME01/2011] ≥ 7.0 log10 EID50/dose.
  • Inactivated Avian Infectious Bronchitis Virus, GI-13 (variant-1) [ME/IBV-VAR1/2017] ≥ 7.0 log10 EID50/dose.
  • Inactivated Avian Infectious Bronchitis Virus, GI-23 (variant-2) [Eg/1212B] ≥ 7.0 log10 EID50/dose. 
  • Inactivated Newcastle Disease Virus GII LaSota strain [NDV/Chicken/Egypt/11478AF/2011] ≥ 8.5 log10 EID50/dose.
  • Inactivated Newcastle Disease Virus GVII strain [r’NDV1/ME.G7/2017] ≥ 8.5 log10 EID50/dose.

Indications

For booster immunization of chickens to protect against Avian Infectious Bronchitis (GI-1, GI-13, and GI-23 lineages) and Newcastle Disease.

Vaccination Program

Birds can be vaccinated from 14 days of age onwards, as per advice from your poultry veterinarian. Layer, Breeders and grandparent flocks should be vaccinated at least 4 weeks before the onset of lay. For an optimal booster effect, the birds must be primed with live vaccine against Newcastle Disease and Infectious Bronchitis Virus.

Dosage

The vaccine dose (0.5 mL/bird) should be administered subcutaneously in the lower part of the neck or intramuscularly in the thigh or breast muscles.

Immunity

  • Onset of immunity: 3 weeks after primary vaccination.
  • Duration of immunity: until 6 weeks after single dose.

Considerations

  • Vaccine bottles shall be shaken well before use.
  • Use sterile injection equipment.

Withdrawals

Zero days.

Administration

Before use, the vaccine should be shaken well to ensure proper mixing. Sterile injection equipment should be used to avoid contamination. 

  • Subcutaneous injection: in the lower part of the neck. The needle should be inserted just under the skin in a direction away from the head and in a straight line with the neck.
  • Intramuscular injection: in the breast muscles by inserting the needle with a 45° angle to avoid intraperitoneal injection. 

Storage Precautions

  • Store and transport refrigerated (2 °C to 8 °C).
  • Do not freeze.
  • Store in a dry place protected from direct light.
  • Do not use this product after the expiry date.
  • Shelf life after first opening the bottle: 3 hours.
MEVAC™ MULTI IB+ND7

Presentation

MEVAC™ MULTI IB+ND7 is packed and presented in 500 mL (1000 doses) polyethylene terephthalate (PET) bottles.

Download the Product Information Sheet

MEVAC™ MULTI IB+ND7 product information...
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References

1. Hang X., Liao K., et.al, Evaluation of the reproductive system development and egg-laying performance of hens infected with TW I-type infectious bronchitis virus. Vet. Res. 2020;51:95.

2. Ganapathy K., Wilkins M., Forrester A., Lemiere S., Cserep T., McMullin P., Jones R.C. QX-like infectious bronchitis virus isolated from cases of proventriculitis in commercial broilers in England. Vet.

3. Shaw K., Britton P., Cavanagh D. Sequence of the spike protein of the Belgian B164S isolate of nephropathogenic infectious bronchitis virus. Avian Pathol. 1996.

4. Ackwood M.W. Review of infectious bronchitis virus around the world. Avian Dis. 2012.

5. Fields, D.B. 1973. Arkansas 99, a new infectious bronchitis serotype. Avian Diseases.

6. Morley, A.J. and Thomson, D.K. 1984. Swollen-head syndrome in broiler chickens. Avian Diseases.

7. Lohr, J.E. (1988). Infectious bronchitis in New Zealand, Asia, East Europe. In E.F. Kaleta & U. Heffels-Redmann (Eds.). Proceedings of the 1st International Symposium on Infectious Bronchitis.

8. Anjatovic, J., Gould, G. and Sapats, S. 2006. Isolation of a variant infectious bronchitis virus in Australia that further illustrates diversity among emerging strains.

9. Houta, M.H., Hassan, K.E., El-Sawah, A.A. et al. Jan.2021.

10. Sultan et al (2021). Efficacy of the Newcastle Disease Virus Genotype VII.1.1-Matched Vaccines in Commercial Broilers. Vaccines (Basel). 2022 Jan; 10(1): 29.

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