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Revolutionizing Gut Health: Introducing ButiShield™ – Kemin's Breakthrough in Microencapsulated Calcium Butyrate

Posted December 19, 2023

At Kemin Industries, our commitment to sustainably transforming lives drives us to constantly innovate and overcome challenges in the nutraceutical industry. We are thrilled to introduce our latest breakthrough – ButiShield™, an encapsulated form of calcium butyrate designed specifically for humans, designed to fortify overall gut health. In this blog post, we'll delve into the details of ButiShield™ and explore how it addresses common challenges faced by supplement manufacturers.

The Butyric Acid Advantage:

Butyric acid, an extensively researched short-chain fatty acid (SCFA), is a key player in intestinal health, influencing overall well-being. Despite its remarkable benefits, the incorporation of butyrate into products has been hindered by formulation and operational challenges, primarily due to its unpleasant odor.

The Innovation: ButiShield™ with MicroPEARLS™ Technology

To overcome these challenges, Kemin is proud to present ButiShield™, crafted using our patented MicroPEARLS spray freezing technology. This innovative approach involves encapsulating butyric acid which ensures a sustained and controlled release along the gastrointestinal tract . Notably, MicroPEARLS™ technology also addresses the handling issue by significantly reducing the odor associated with butyric acid.

Key Features of ButiShield™:

Low Odor: MicroPEARLS™ encapsulation technology neutralizes the typically off-putting odor of butyric acid, providing a more pleasant experience for consumers.

Versatile Solution: ButiShield™ is a low-odor, non-GMO, allergen-free, gluten-free, kosher, halal, and vegetarian ingredient solution, offering greater than 35% butyric acid.

Science-Backed Benefits:

ButiShield™, with its microencapsulated butyrate delivers a vital metabolite of fiber fermentation with robust scientific validation. It works by:*1-8

  1. Shaping a Healthy Microbiome: Contributing to the creation of a healthy gastrointestinal environment.
  2. Cellular Regulation: Serving as a signaling molecule to regulate numerous metabolic processes at the cellular level.
  3. Energy Source: Serving as a primary energy source for healthy intestinal cells.
  4. Intestinal Barrier Support: Supporting intestinal barrier integrity.

Conclusion:

As a leading global ingredient manufacturer, Kemin is proud to present ButiShield™ as a game-changer in the digestive health category. This microencapsulated calcium butyrate opens new possibilities for supplement manufacturers, providing a unique solution to the evolving gut health market. With ButiShield™, we're not just addressing challenges; we're revolutionizing gut health and offering a novel approach to incorporating butyrate into formulations. Click here to explore the myriad benefits of ButiShield™ for intestinal and whole-body health.


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*These statements have not been evaluated by the US Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. The information on this webpage is a business-to-business information and not intended for the final consumer. Certain statements may not be applicable in all geographical regions. Product labeling and associated claims differs based upon government requirements and country or region specific information should also be considered when labeling or advertising to final consumers. This web page and its associated brochures and other documents do not constitute or provide scientific or medical advice, diagnosis, or treatment and are distributed without warranty of any kind, either expressly or implied. This web page, its title or contents and associated brochures and other documents do not in any way make recommendations for health or marketing claims by the reader. Country and region specific regulations should be considered in this regard. Each claim or statement about the effectiveness of Kemin products and/or each claim or statement comparing the effectiveness of Kemin products to the effectiveness of other products is expressly limited to the United States, unless otherwise disclosed on the Kemin websites.

References

  1. Donohoe, D.R., Garge, N., Zhang, X., Sun, W., O'Connell, T.M., Bunger, M.K. and Bultman, S.J., 2011. The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Cell metabolism, 13(5), pp.517-526.
  2. Yan, H. and Ajuwon, K.M., 2017. Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway. PloS one12(6), p.e0179586.
  3. Peng, L., Li, Z.R., Green, R.S., Holzman, I.R. and Lin, J., 2009. Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers. The Journal of nutrition139(9), pp.1619-1625.
  4. Bach Knudsen, K.E., Lærke, H.N., Hedemann, M.S., Nielsen, T.S., Ingerslev, A.K., Gundelund Nielsen, D.S., Theil, P.K., Purup, S., Hald, S., Schioldan, A.G. and Marco, M.L., 2018. Impact of diet-modulated butyrate production on intestinal barrier function and inflammation. Nutrients, 10(10), p.1499.
  5. Facchin, S., Vitulo, N., Calgaro, M., Buda, A., Romualdi, C., Pohl, D., Perini, B., Lorenzon, G., Marinelli, C., D’Incà, R. and Sturniolo, G.C., 2020. Microbiota changes induced by microencapsulated sodium butyrate in patients with inflammatory bowel disease. Neurogastroenterology & Motility, 32(10), p.e13914.
  6. Gao, F., Lv, Y.W., Long, J., Chen, J.M., He, J.M., Ruan, X.Z. and Zhu, H.B., 2019. Butyrate improves the metabolic disorder and gut microbiome dysbiosis in mice induced by a high-fat diet. Frontiers in Pharmacology, 10, p.1040.
  7. Louis, P. and Flint, H.J., 2009. Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine. FEMS microbiology letters294(1), pp.1-8.
  8. Vital, M., Karch, A. and Pieper, D.H., 2017. Colonic butyrate-producing communities in humans: an overview using omics data. Msystems, 2(6), pp.e00130-17.