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References:
- Wooten BR, Hammond BR. Macular pigment: Influences on visual acuity and visibility. Prog Retin Eye Res. 2002;21(2):225–40.
- Krinsky NI, Landrum JT, Bone RA. Biologic mechanism of the protective role of Lutein and Zeaxanthin in the Eye. Annu Rev Nutr. 2003;23:171–201.
- Kritchevsky SB, Bush AJ, Pahor M, Gross MD. Serum carotenoids and markers of inflammation in nonsmokers. Am J Epidemiol. 2000;152(11):1065–71.
- Gruszecki WI, Strzałka K. Carotenoids as modulators of lipid membrane physical properties. Biochim Biophys Acta - Mol Basis Dis. 2005;1740(2):108–15
- Oostenbrug GS, Mensink RP, Al MDM, van Houwelingen AC, Hornstra G. Maternal and neonatal plasma antioxidant levels in normal pregnancy, and the relationship with fatty acid unsaturation. Br J Nutr. 1998;80(1):67–73.
- Khachik F, Spangler CJ, Smith JC, Canfield LM, Steck A, Pfander H. Identification, Quantification, and Relative Concentrations of Carotenoids and Their Metabolites in Human Milk and Serum. Anal Chem. 1997 May 15;69(10):1873–81.
- Patton S, Canfield LM, Huston GE, Ferris AM, Jensen RG. Carotenoids of human colostrum. Lipids. 1990;25(3):159–65.
- Sherry CL, Oliver JS, Renzi LM, Marriage BJ. Lutein Supplementation Increases Breast Milk and Plasma Lutein Concentrations in Lactating Women and Infant Plasma Concentrations but Does Not Affect Other Carotenoids. J Nutr. 2014;144(8):1256–63.
- Cena H, Castellazzi AM, Pietri A, Roggi C, Turconi G. Lutein concentration in human milk during early lactation and its relationship with dietary lutein intake. Public Health Nutr. 2009;12(10):1878–84.
- Neuringer M, Bone RA, Jeffrey B, Bettler J, Zimmer JP, Wallace P, et al. Lutein in Breastmilk and Infant Formula: Effects on Serum Lutein, Macular Pigment and Visual Function. Invest Ophthalmol Vis Sci [Internet]. 2009;50(13):1707. Available from: https://iovs.arvojournals.org/article.aspx?articleid=2364128
- Liu Z, Meyers KJ, Johnson EJ, Snodderly M, Tinker L, Wallace R, et al. Exposure to Lutein in Infancy via Breast Milk and Later Life Macular Pigment Optical Density. Investig Ophthalmol Vis Sci [Internet]. 2015;56(7):192. Available from: http://iovs.arvojournals.org/article.aspx?articleid=2331661 http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed16&NEWS=N&AN=615917349
- Bone RA, Landrum JT, Fernandez L, Tarsis SL. Analysis of the macular pigment by HPLC: Retinal distribution and age study. Investig Ophthalmol Vis Sci. 1988;29(6):843–9.
- Vishwanathan R, Kuchan MJ, Sen S, Johnson EJ. Lutein is the predominant carotenoid in infant brain: Preterm infants have decreased concentrations of brain carotenoids. J Pediatr Gastroenterol Nutr. 2014;59(5):659–65.
- Bone RA, Landrum JT, Fernandez L, Tarsis SL. Analysis of the macular pigment by HPLC: Retinal distribution and age study. Investig Ophthalmol Vis Sci. 1988;29(6):843–9
- Bernstein PS, Sharifzadeh M, Liu A, Ermakov I, Nelson K, Sheng X, et al. Blue-light reflectance imaging of macular pigment in infants and children. Investig Ophthalmol Vis Sci. 2013;54(6):4034–40
- Neuringer M, Bone RA, Jeffrey B, Bettler J, Zimmer JP, Wallace P, et al. Lutein in Breastmilk and Infant Formula: Effects on Serum Lutein, Macular Pigment and Visual Function. Invest Ophthalmol Vis Sci [Internet]. 2009;50(13):1707. Available from: https://iovs.arvojournals.org/article.aspx?articleid=2364128
- Liu Z, Meyers KJ, Johnson EJ, Snodderly M, Tinker L, Wallace R, et al. Exposure to Lutein in Infancy via Breast Milk and Later Life Macular Pigment Optical Density. Investig Ophthalmol Vis Sci [Internet]. 2015;56(7):192. Available from: http://iovs.arvojournals.org/article.aspx?articleid=2331661 http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed16&NEWS=N&AN=615917349
- Lai, J.S.; Veetil, V.O.; Lanca, C.; Lee, B.L.; Godfrey, K.M.; Gluckman, P.D.; Shek, L.P.; Yap, F.; Tan, K.H.; Chong, Y.S.; et al. Maternal Lutein and Zeaxanthin Concentrations in Relation to Offspring Visual Acuity at 3 Years of Age: The GUSTO Study. Nutrients 2020, 12, 1–11, doi:10.3390/nu12020274
- Mahmassani, H.A.; Switkowski, K.M.; Scott, T.M.; Johnson, E.J.; Rifas-Shiman, S.L.; Oken, E.; Jacques, P.F. Maternal Intake of Lutein and Zeaxanthin during Pregnancy Is Positively Associated with Offspring Verbal Intelligence and Behavior Regulation in Mid-Childhood in the Project Viva Cohort. J. Nutr. 2021, 151, 615–627, doi:10.1093/jn/nxaa348.
- Cheatham, C.L.; Sheppard, K.W. Synergistic Effects of Human Milk Nutrients in the Support of Infant Recognition Memory: An Observational Study. Nutrients 2015, 7, 9079–9095, doi:10.3390/nu7115452.
- Capeding R, Gepanayao CP, Calimon N, Lebumfacil J, Davis AM, Stouffer N, et al. Lutein-fortified infant formula fed to healthy term infants: Evaluation of growth effects and safety. Nutr J. 2010;9(1):1–9.
- Mackey AD, Albrecht D, Oliver J, Williams T, Long AC, Price PT. Plasma carotenoid concentrations of infants are increased by feeding a milk-based infant formula supplemented with carotenoids. J Sci Food Agric. 2013;93(8):1945–52.
- Bettler J, Zimmer JP, Neuringer M, Derusso PA. Serum lutein concentrations in healthy term infants fed human milk or infant formula with lutein. Eur J Nutr. 2010;49(1):45–51.
- Perrone S, Longini M, Marzocchi B, Picardi A, Bellieni C V., Proietti F, et al. Effects of Lutein on Oxidative Stress in the Term Newborn: A Pilot Study. Neonatology [Internet]. 2010;97(1):36–40. Available from: https://www.karger.com/Article/FullText/227291
- Perrone S, Tei M, Longini M, Santacroce A, Turrisi G, Proietti F, et al. Lipid and protein oxidation in newborn infants after lutein administration. Oxid Med Cell Longev. 2014;2014.
- Systemic Effects of Prenatal Carotenoid Supplementation in the Mother and her Child: The Lutein and Zeaxanthin in Pregnancy (L-ZIP) Randomized Trial–Report Number 1
- Gorka, J.E., Addo, E.K., Allman, S., Harrison, D.Y., Brintz, B., Sharifzadeh, M., Hartnett, M.E. and Bernstein, P.S., 2023. The Effects of Prenatal Carotenoid Supplementation on Infant Foveal Maturity: The Lutein and Zeaxanthin in Pregnancy (L-ZIP) Trial. Investigative Ophthalmology & Visual Science, 64(8), pp.5203-5203.
- Bernstein, P.S., Addo, E.K., Allman, S., Arunkumar, R. and Varner, M., 2023. Maternal Ocular and Systemic Effects of Prenatal Carotenoid Supplementation in the Lutein and Zeaxanthin in Pregnancy (L-ZIP) Trial. Investigative Ophthalmology & Visual Science, 64(8), pp.1417-1417.
- Rubin, L.P.; Chan, G.M.; Barrett-Reis, B.M.; Fulton, A.B.; Hansen, R.M.; Ashmeade, T.L.; Oliver, J.S.; MacKey, A.D.; Dimmit, R.A.; Hartmann, E.E.; et al. Effect of Carotenoid Supplementation on Plasma Carotenoids, Inflammation and Visual Development in Preterm Infants. J. Perinatol. 2012, 32, 418–424, doi:10.1038/jp.2011.87.
- Kemin Internal Document TD-18-4987 - Randomized, DBPCP Pilot Study to Evaluate the Effects of Lutein Supplementation on Visual Performance Following Blue Light Exposure in school-aged children
- USDA-NNCC. Carotenoid Database for U.S. Foods [Internet]. 1998. Available from: www.usda.gov
- Stahl W. Macular carotenoids: lutein and zeaxanthin. Dev Ophthalmol. 2005;38:70–88.
- Johnson EJ, Maras JE, Rasmussen HM, Tucker KL. Intake of lutein and zeaxanthin differ with age, sex, and ethnicity. J Am Diet Assoc [Internet]. 2010;110(9):1357–62. Available from: http://dx.doi.org/10.1016/j.jada.2010.06.009
- KHTL-017-083
- AREDS 2 TA-REDS 2 R. Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: The Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. JAMA - J Am Med Assoc. 2013;309(19):2005–15
- JECFA. Lutein from Tagetes erecta. Chemical and Technical Assessment [Internet]. 2004. Available from: http://www.fao.org/fileadmin/templates/agns/pdf/jecfa/cta/63/Lutein.pdf%0A
- Scientific Opinion of the Panel on Dietetic Products N and A. Safety, bioavailability and suitability of lutein for the particular nutritional use by infants and young children [Internet]. 2008. Available from: https://www.efsa.europa.eu/fr/efsajournal/pub/823
- GRAS. U.S. Food & Drug Administration, 2004.GRAS Notice Inventory, GRN No. 140, 221 and 390.