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VIBRIO-VAC™

Product Overview

VIBRIO-VAC™ is an inactivated trivalent bacterial vaccine for immunizing fish against the included Vibro and Photobacterium species.

Target Species

Marine water fishes.

Immunocompetence Aqua

Vibriosis in hatchery and grow-out fish facilities

Vibriosis is among the most common diseases leading to massive mortality of cultured shrimp, fish, and shellfish in Asia. High incidence of vibriosis can occur in hatchery and grow-out facilities, but juveniles are more susceptible to the disease. Various factors, particularly the source of fish, environmental factors (including water quality and farm management), and the virulence factors of Vibrio, influence the occurrence of the disease.1

Affected fish show weariness, with necrosis of skin and appendages, leading to body malformation, slow growth, internal organ liquefaction, blindness, muscle opacity, and mortality. A combination of control measures, particularly a disease-free source of fish, biosecurity of the farm, improved water quality, and other preventive measures (e.g. vaccination) might be able to control the infection. Although some control measures are expensive and less practical, vaccination is effective, relatively cheap, and easily implemented.1

Some Vibrio strains can cause fatal diarrhoeal illness in humans through contaminated water and food. V. harveyi has also been reported as an opportunistic pathogen in humans causing wound infections after contact with seawater.2

With the increasing incidence of vibriosis among marine organisms that lead to severe disease outbreaks, attempts to control this infection is a major concern.2

Product Description

Composition (before inactivation)

  • Inactivated Vibrio alginolyticus strain ≥ 3.0 x 108.0 CFU / dose.
  • Inactivated Vibrio harvyei strain ≥ 3.0 x 108.0 CFU / dose.
  • Inactivated Photobacterium damselae strain ≥ 3.0 x 108.0 CFU / dose.

Indications

For immunization of commercial fish systems against Vibrio and Photobacterium infections.

Vaccination Program

Fish can be vaccinated from 21 days of age onwards, as per advice from your aqua veterinarian.

Withdrawal

Zero days. 

Considerations

  • Vaccinate only healthy fish.
  • Allow the vaccine to reach room temperature (+20 to +25°C. before use).
  • Do not mix with other veterinary products. 
  • Fish should be vaccinated 14 days before ponding or anticipated exposure to infection.
VIBRIO-VAC™

Administration

Before use, the vaccine should be shaken well to ensure proper mixing. Sterile injection equipment should be used to avoid contamination.

  • Immersion vaccination: vaccine uptake may occur through the gills therefore fish need to be fully immersed in a diluted solution containing the vaccine for 2-5 minutes after which they are returned to the holding tanks. The vaccine solution should be clean and well oxygenated. The temperature of the diluted vaccine shall not deviate from the water temperature in the holding area by more than ±5 °C. Vaccinate the correct weight of fish: 1 liter of vaccine diluted in 9 liters of water is sufficient to vaccinate 100 kg. of fish.
  • Parenteral injection: the injectable dose (0.2 mL/fish) should only be applied by intraperitoneal (IP) or intramuscular (IM) route in fish over 15 g weight. Prior vaccination the fish should be anaesthetized, and the needle should penetrate the muscle in order to deposit the vaccine volume in the peritoneal cavity or in the dorsal muscle.

Storage Precautions

  • Store and transport refrigerated (+2°C to +8°C).
  • Do not freeze.
  • Store in a dry place protected from direct sunlight.
  • Do not use this product after the expiry date.
  • Shelf life after first opening the bottle: 3 hours.

Presentation

VIBRIO-VAC™ is packed and presented in 500 mL (2,500 doses) polyethylene terephthalate (PET) bottles.

Download the Product Information Sheet

VIBRIO-VAC™ product information sheet
Download

References

1. Anim Health. 2019 Mar;31(1):3-22. doi: 10.1002/aah.10045. Epub 2018 Dec 10.

2. Manchanayake et al (2023). Pathology and pathogenesis of Vibrio infection in fish: A review. Aquaculture Reports, Volume 28, February 2023, 101459.

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The content on this site is intended for informational purposes only and is not intended to be a substitute for professional veterinary advice. Although the information on this site is accessible worldwide, not all products or services are available to all persons or in all geographic locations or jurisdictions. Certain statements, product labeling and claims may differ by geography or as required by local governmental regulations.