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MEVAC™ MULTI IB+H9+ND

Product Overview

MEVAC™ MULTI IB+H9+ND is an inactivated pentavalent vaccine for immunization against IBV (Classic M41, GI-13 and GI-23 strains), LPAI subtype H9N2 and ND GII virus.

Target Species

Chickens.

Respiratory Integrity Poultry

Co-infections with Infectious Bronchitis, Newcastle Disease and Avian Influenza

The Infectious Bronchitis Virus (IBV) poses a significant threat to the poultry industry due to its highly contagious nature and its capacity to cause acute infections in chickens.1,2

To combat IBV, vaccination stands as the key strategy. However, the global prevalence of both classical and variant IBVs, coupled with the limited efficacy of traditional Mass-type vaccines against multiple IBV variants, presents considerable challenges for effective control.3,4 These variants have been identified across various regions, such as: Latin America5, Africa6, Asia7, and Australia8. Understanding the genetic diversity of IBV has led to the classification of 32 lineages within 6 genotypes based on analysis of the S1 gene. While certain lineages like GI-1, GI-13, and GI-19 exhibit broad distribution, notably, the GI-23 lineage, initially confined to the Middle East, has now gained prominence and extends its presence to Europe, Asia, and Africa, indicating its expanding geographical influence over time.9

Infections resulting from the low pathogenic avian influenza (LPAI) subtype H9N2 continue to pose a substantial threat to poultry populations in Asia, the Middle East, and Africa.1 The implications of H9N2 virus infections are far-reaching, leading to economic losses across various poultry sectors, including layers, breeders, and broilers. The impact includes a significant decline in egg production, up to 20%, which can be increased by potential co-infections with major respiratory viruses such as Infectious Bronchitis Virus (IBV) and Newcastle disease virus (NDV).10

Product Description

Composition (before inactivation)

  • Inactivated Avian Infectious Bronchitis Virus, GI-1 lineage (classic) [IBV-EG/M41-ME01/2011] ≥ 7.0 log10 EID50/dose.
  • Inactivated Avian Infectious Bronchitis Virus, GI-13 (variant-1) [ME/IBV-VAR1/2017] ≥ 7.0 log10 EID50/dose.
  • Inactivated Avian Infectious Bronchitis Virus, GI-23 (variant-2) [Eg/1212B] ≥ 7.0 log10 EID50/dose. 
  • Inactivated Low Pathogenic Avian influenza H9N2 subtype [A/Chicken/Egypt/ME543V/2016] belonging to G1 lineage ≥ 8.5 log10 EID50/dose.
  • Inactivated Newcastle Disease Virus GII LaSota strain [NDV/Chicken/Egypt/11478AF/2011] ≥ 8.5 log10 EID50/dose.

Indications

For booster immunization of chickens to protect against Avian Infectious Bronchitis (GI-1, GI-13, and GI-23 lineages), Low Pathogenic Avian influenza H9N2 subtype, and Newcastle Disease.

Vaccination Program

Birds can be vaccinated from 14 days of age onwards, as per advice from your poultry veterinarian. A booster dose may be required in case of high-risk seasons and areas. For optimal booster effects, the birds should be primed with live NDV and IBV vaccines.

Dosage

The vaccine dose (0.5 mL/bird) should be administered subcutaneously in the lower part of the neck or intramuscularly in the thigh or breast muscles.

Withdrawals

Zero days.

Administration

Before use, the vaccine should be shaken well to ensure proper mixing. Sterile injection equipment should be used to avoid contamination.

  • Subcutaneous injection: in the lower part of the neck. The needle should be inserted just under the skin in a direction away from the head and in a straight line with the neck.
  • Intramuscular injection: in the breast muscles by inserting the needle with a 45° angle to avoid intraperitoneal injection. 

Storage Precautions

  • Store and transport refrigerated (+2°C to +8°C). 
  • Do not freeze.
  • Store in a dry place protected from direct sunlight.
  • Do not use this product after the expiry date.
  • Shelf life after first opening the bottle: 3 hours.
MEVAC™ MULTI IB+H9+ND

Presentation

MEVAC™ MULTI IB+H9+ND is packed and presented in 250 mL (500 doses),  300 mL (600 doses) and 500 mL (1000 doses), polyethylene terephthalate (PET) bottles.

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References

1. Hang X., Liao K., et.al, Evaluation of the reproductive system development and egg-laying performance of hens infected with TW I-type infectious bronchitis virus. Vet. Res. 2020;51:95.

2. Ganapathy K., Wilkins M., Forrester A., Lemiere S., Cserep T., McMullin P., Jones R.C. QX-like infectious bronchitis virus isolated from cases of proventriculitis in commercial broilers in England. Vet.

3. Shaw K., Britton P., Cavanagh D. Sequence of the spike protein of the Belgian B164S isolate of nephropathogenic infectious bronchitis virus. Avian Pathol. 1996.

4. Ackwood M.W. Review of infectious bronchitis virus around the world. Avian Dis. 2012.

5. Fields, D.B. 1973. Arkansas 99, a new infectious bronchitis serotype. Avian Diseases.

6. Morley, A.J. and Thomson, D.K. 1984. Swollen-head syndrome in broiler chickens. Avian Diseases.

7. Lohr, J.E. (1988). Infectious bronchitis in New Zealand, Asia, East Europe. In E.F. Kaleta & U. Heffels-Redmann (Eds.). Proceedings of the 1st International Symposium on Infectious Bronchitis.

8. Anjatovic, J., Gould, G. and Sapats, S. 2006. Isolation of a variant infectious bronchitis virus in Australia that further illustrates diversity among emerging strains.

9. Houta, M.H., Hassan, K.E., El-Sawah, A.A. et al. Jan.2021.

10. Guan Y, et.al . (2000) H9N2 influenza viruses possessing H5N1-like internal genomes continue to circulate in poultry in southeastern China.

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