References
1. Euglena gracilis ATCC PTA-123017
2. Salminen, et al. Nat rev Gastroenterol Hepatol (2022). https://www.nature.com/articles/s41575-021-00440-6
3. Evans, M., et al., Effect of a Euglena gracilis Fermentate on Immune Function in Healthy, Active Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients, 2019, 11(12), 2926
4. Kemin, BetaVia Complete can prime key cells in the innate immune system. KHTL-017-150.
5. KHTL-017-162 BetaVia Pure Can Prime Key Cell sin the Innate Immune system. KHTL-017-150.
6. KHTL-017-160 Paramylon Improves Antioxidant Status and Metabolic Health-TL-20-18529
7. KHTL-017-149 Characteristics and Prebiotic like Properties of BetaVia Complete
8. Kemin, Characteristics and prebiotic like properties of BetaVia Complete. KHTL-017-149.
9. Bhattad T, Koradiya A, Prakash G. Prebiotic activity of paramylon isolated from heterotrophically grown Euglena gracilis. Heliyon. 2022 Aug 27;7 (9): e07884. doi: 10.1016/j.heliyon.2022.e07884
10. Russo, R., et al. “Euglena gracilis paramylon activates human lymphocytes by upregulating pro-inflammatory factors.” Food Science & Nutrition 5.2 (2017): 205-214
11. Kondo, Y., et al. "Cytokine-related immunopotentiating activities of Paramylon, a β-(1→ 3)-D-glucan from Euglena gracilis." Journal of Pharmacobio-dynamics 15.11 (1992): 617-621.
12. Kankkunen, P., et al. "(1, 3)-β-Glucans activate both dectin-1 and NLRP3 inflammasome in human macrophages." The Journal of Immunology 184.11 (2010): 6335-6342
13. Brown, G.D., and Siamon G. Immune recognition: A new receptor for [beta]-glucans." Nature 413.6851 (2001): 36.
14. Brown, G.D., et al. "Dectin-1 is a major β-glucan receptor on macrophages. Journal of Experimental Medicine 196.3 (2002): 407-412.
15. Brown, G.D., et al. Dectin-1 mediates the biological effects of β-glucans." Journal of Experimental medicine 197.9 (2003): 1119-1124.
16. Goodridge, H.S. et al. "β‐glucan recognition by the innate immune system. Immunological reviews 230.1 (2009): 38-50.
17. KEMIN internal document: SD-18-00083
18. Ishibashi, Ken-ichi, et al. “Effects of Euglena gracilis EOD-1 ingestion on salivary IgA reactivity and health-related quality of life in humans.” Nutrients 11.5 (2019): 1144.
19. Nakashima, Ayaka, et al. “The alga Euglena gracilis stimulates Faecalibacterium in the gut and contributes to increased defecation.” Scientific reports 11.1 (2021): 1-8.
20. Nakashima, Ayaka, et al. “Effects of Euglena gracilis Intake on Mood and Autonomic Activity under Mental Workload, and Subjective Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Trial.” Nutrients 12.11 (2020): 3243.
21. Kawano, Takanori, et al. “Effect of Food Containing Paramylon Derived from Euglena gracilis EOD-1 on Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trail.” Nutrients 12.10 (2020): 3098.
22. SD-17-00243 Kemin Internal Document (Effect of 50%BG on the immune and intestinal health status of weaned piglets)
23. SD-9-21271 Kemin Internal Document (Effect of 50% BG on IgA in piglet feces)
24. TD-17-0322 Kemin Internal Document (Effect of 50% and 95% BG on gut and systemic immunity in mice)
25. KHTL-017-159 BetaVia Complete Supports Gut Health after Induced Colitis in Mice
26. Kemin Proprietary Data TD-20-6867
27. Vighi, G., Marcucci, F., Sensi, L., Di Cara, G., & Frati, F. (2008). Allergy and the gastrointestinal system. Clinical and experimental immunology, 153 Suppl 1(Suppl 1), 3–6. https://doi.org/10.1111/j.1365-2249.2008.03713.x
28. Patents granted a patent on beta 1,3 glucans for modulating immune function (US Patent 10,912,794). This new patent joins a previously issued patent, US 9574217,on the production of immune modulation using algae from a proprietary strain of Euglena gracilis ATCC PTA-123017.
29. KHTLA-017-181 BetaViaTM helps to Maintain Health and Promote Gut Health by Supporting Intestinal Barrier Integrity
30. KHTLA-017-180 BetaViaTM A Natural New-Generation Postbiotic that works as both an Immune Gut Health Promoter
31. KHTLA-017-148 (TL-20-18591) Characteristics and Prebiotic like properties of BetaVia Complete