VANNIX™ C is a proprietary formulation of tannic acid and a direct-fed microbial designed to improve poultry intestinal health and performance efficiency. By combining the unique benefits of tannic acid – a natural plant extract – and probiotics, VANNIX C helps minimize factors that can challenge intestinal integrity, thereby allowing birds to reach their performance potential.
Tannins are plant-derived polyphenolic compounds, which are classified by their structure into two groups: hydrolysable tannins and condensed tannins. Condensed tannins are found in sorghum and are typically considered anti-nutritive for poultry. In contrast, hydrolysable tannins – like the tannic acid found in VANNIX C – are produced as a part of the plant defensive response to environmental or pathogen challenge. Research has shown that tannic acid may provide benefits to intestinal health through antioxidant, anti-inflammatory and astringent activities.3 Additionally, tannic acid has known anti-parasitic activity4 and has been shown in research to inhibit growth of several common poultry pathogens.5,6 With these multiple activities, one intriguing application of tannic acid could be as a solution for coccidiosis.7
VANNIX C combines the functional benefits of natural plant extracts and active microbial ingredients to provide producers with a cost-effective solution to support poultry intestinal integrity and overall performance. During the development of VANNIX C, numerous plant extracts and direct-fed microbial combinations were evaluated in order to formulate an optimal mixture to support overall health and performance. The resulting formula has consistently been shown to reduce coccidiosis lesion scores, lower oocyst counts and improve broiler performance.1 VANNIX C has been shown to support coccidiosis-vaccinated birds maintain performance.1
The tannic acid used in VANNIX C is a natural extract from gallnuts (60-70% hydrolysable tannins). The tannic acid is further processed into a proprietary blend of tannic acid – referred to as tannic acid extract – with enhanced bioactivity towards pathogens. Tannic acid extract has been shown to reduce the viability of Eimeria sporozoites in vitro (Figure 1) as well as to decrease intestinal lesions and Eimeria oocyst shedding during a coccidiosis challenge.1 The observed reduction in Eimeria challenge may be related to direct action of tannic acid extract against the Eimeria parasite5,6,8 or through antioxidant, anti-inflammatory and astringent activities which support intestinal health.
Figure 1. In vitro assay for reducing the viability of Eimeria tenella sporozoites.8
Bacillus coagulans is a unique, spore-forming microorganism that supports intestinal microflora balance in livestock and poultry. Unlike other Bacillus organisms, Bacillus coagulans produces lactic acid and acetic acids, which may provide antimicrobial benefits.9 Research has shown Bacillus coagulans can positively influence innate immunity.10,11
VANNIX C is sold in 25 kg bags. Store in a cool, dry place out of direct sunlight for maximum shelf-life.
1Tonda, R.M., J.K. Rubach, B.S. Lumpkins, G.F. Mathis, and M.J. Poss. 2018. Effects of tannic acid extract on performance and intestinal health of broiler chickens following coccidiosis vaccination and/or a mixed-species Eimeria challenge. Poultry Science. 97:3031-3042.
2Kemin Internal Document, 16-00078.
3Hamiza, O.O., M.U. Rehman, M. Tahir, R. Khan, A.Q. Khan, A. Lateef, F. Ali, and S. Sultana. 2012. Amelioration of 1,2 Deimethylhydrazine (DMH) induced colon oxidative stress, inflammation and tumor promotion response by tannic acid in wistar rats. Asian Pac. J. Cancer Prev. 13:4393-4402.
4Min, B.R. and S.P. Hart. 2003. Tannins for suppression of internal parasites. J. Anim. Sci. 81(E. Suppl. 2):E102-E109.
5Scalbert, A. 1991. Antimicrobial properties of tannins. Phytochemistry. 30:3875-3883.
6Chung, K.T., Z. Lu, and M.W. Chou. 1998. Mechanism of inhibition of tannic acid and related compounds on the growth of intestinal bacteria. Food Che. Toxicol. 36:1053-1060.
7Kaleem, Q.M., M. Akhtar, M.M. Awaid, M. Saleem, M. Zafar, Z. Iqbal, F. Muhammad, and M.I. Anwar. 2014. Studies on Emblica officinalis derived tannins for their immunostimulatory and protective activities against coccidiosis in industrial broiler chickens. The Scientific World Journal. 2014:378473-378483.
8Kemin Internal Document, 14-00032.
9Kemin Internal Document, 15-00033.
10Lin, S.Y., A.T.Y. Hung, and J.J. Lu. 2011. Effects of supplement with different levels of Bacillus coagulans as probiotics on growth performance and intestinal microflora populations of broiler chickens. J. of Animal and Veterinary Advances. 10:111-114.
11Lin, S., S. Mao, Y. Guan, L. Luo, L. Luo, and Y. Pan. 2012. Effects of dietary chitosan oligosaccharides and Bacillus coagulans on the growth, innate immunity and resistance of koi (Cyprinus carpio koi). Aquaculture. 342-343:36-41.
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