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CLOSTAT® Active Microbial for Beef and Dairy Cattle

The Problem is In the Gut   

Every day, through their environment, animals are exposed to pathogens, including Clostridia, Salmonella and E. coli. This exposure can impact the microbiota of the gastrointestinal tract.

Stress + Pathogenic Bacteria = Gut Health Challenge

Under stress events, both the mucosal layer and the tight junctions are negatively impacted, often leading to inflammation and reduced integrity of the intestinal barrier.


To optimize animal health, performance and profitability, you must optimize intestinal health.

CLOSTAT® contains a unique, patented spore-forming strain of Bacillus subtilis PB6. With a known mode of action, and over 15 years of research in livestock and poultry across the globe, PB6 has proven efficacy against Clostridia and other pathogenic species.1

CLOSTAT® for Ruminants Brochure





Gut health beyond the rumen: Why the GI tract should be a core focus of your herd's health


Understanding how the gastrointestinal (GI) tract functions, how it contributes to overall ruminant health and what to do when it's compromised are critical to the success of your herd.


CLOSTAT® Active Microbial Mode of Action for Ruminants


CLOSTAT® contains a proprietary, patented strain of Bacillus subtilis, PB6. Kemin selected PB6 – a unique, naturally-occurring probiotic – because it helps maintain the balance of microflora in the gastrointestinal tract in an array of animals, including dairy and beef cattle.


CLOSTAT® Active Microbial for Ruminants One Pager


The problem is in the gut. Hundreds of millions of dollars are spent on interventions to manage disease in livestock. The most impactful animal diseases are often intestinal in nature. Download our one pager and learn more about how CLOSTAT® can help protect your herd.


Effects of Feeding Bacillus subtilis PB6 Active Microbial on Clinical Health, Performance and Carcass Characteristics of Feedlot Steers


The results of this experiment suggest that the supplementation of PB6 at 13 g/hd/d improves feed efficiency in feedlot cattle.


Evaluation of Bacillus subtilis PB6 to Improve Feedlot Steer Performance


Newly received cattle in a feedlot setting face a host of stressors including: transportation, weaning, environmental changes, and comingling. These stressors can compromise the immune system of calves and lead to illness. As a result of the cattle feeding industry reducing their antibiotic usage, the use of direct fed microbials has become more common within commercial feedlots.



CLOSTAT® Mode of Action


The PB6 in CLOSTAT has been found to secrete one or more biocidal proteins that are inhibitory towards certain strains of pathologenic bacteria such as Clostridium perfringens and other ruminant-specific pathogens.

The Impact of Clostridia and Salmonella on Ruminant Health

Dr. Rand Broadway


Dr. Rand Broadway is a research scientist with the USDA-ARS, Livestock Issues Research Unit in Lubbock, Texas. His program currently focuses on non-pharmaceutical supplements to mitigate the negative effects of diseases such as salmonellosis and Bovine Respiratory Disease. Simultaneously, his research aims to identify pathogenic colonization, migration and translocation patterns to enhance food safety, growth and carcass performance. Dr. Broadway received a B.S. in Biochemistry and a M.S. in Food Science and Technology from Mississippi State University. He received his Ph.D. from the Department of Animal and Food Sciences at Texas Tech University. 

My Calves and Heifers "Look Good," What Does that Really Mean?

Dr. Michael A. Ballou


Dr. Mike Ballou is an Associate Dean for Research, an Associate Professor of Nutritional Immunology in the College of Agricultural Sciences and Natural Resources and the interim chair for the Department of Veterinary Sciences at Texas Tech University. The focus of his research is to determine how nutrition and management influence the health and performance of dairy calves, heifers and periparturient cows. Dr. Ballou received a B.S. in Animal Science from the University of California, Davis, where he remained to complete a Ph.D. in Nutritional Biology with an emphasis in Immunology. In his presentation, "My Calves and Heifers 'Look Good,' What Does that Really Mean?", Dr. Ballou will discuss how we monitor and record benchmarks for herd success and how we use those benchmarks to adjust management strategy.

Cattle Health: It's Complicated!

Dr. Jeff Carroll


Dr. Carroll is a Research Physiologist and Research Leader for the USDA-ARS Livestock Issues Research Unit in Lubbock, Texas, where he leads a team working to develop management practices and alternative production systems to enhance animal wellbeing. In addition, his team is actively addressing methods to mitigate adverse effects of stress and develop alternatives to antimicrobials to enhance health and wellbeing of growing pigs and calves. Dr. Carroll completed his B.S. in Animal Science and his M.S. and Ph.D. in Physiology of Reproduction from Texas A&M University. In his presentation, "Cattle Health: It's Complicated," Dr. Carroll will challenge our thinking on current management practices and review potential alternative ways of managing cattle.



1United States Patent 7 ,247 ,299. Lin, et al. 2007.

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