ButiPEARL® Z is a feed additive containing two powerful nutrients, butyric acid and zinc, to improve intestinal health and performance in swine and poultry. The company's proprietary MicroPEARLS® spray freezing technology allows for the timely release of these two key nutrients throughout an animal's gastrointestinal (GI) tract.
Butyric acid and zinc play an important role in key biological processes affecting the health and performance of production animals. Research indicates butyric acid and zinc are necessary to maintain the structural integrity of swine and poultry GI tract and key in creating a microflora balance. Encapsulating the nutrients ensures delivery all along the intestinal tract to the epithelial cells and tight junction proteins. In addition to the nutritional benefits, encapsulation provides superior handling by reducing the odor associated with butyric acid.
Take a closer look at our proprietary GEM and MicroPEARLS® technologies by watching the following video.
Butyric acid is an integral short-chain fatty acid acting as an energy source for epithelial cells. Butyric acid improves gut health through development of the intestinal epithelium. Benefits of butyric acid for broilers and swine include the upregulation of the expression of tight junction proteins in the intestines1,2 and increases antioxidant levels to promote healing in the GI tract.2 Butyric acid increases epithelial proliferation3 and host defense peptides,4 while also reducing inflammation.4
Zinc benefits swine and poultry as an essential nutrient with a pivotal role in many key biological processes affecting the health and performance of livestock. Zinc serves as a structural role in DNA replication5 and aids in T-cell development.6 It is a cofactor for metabolic enzymes,7 wound healing enzymes8 and antioxidants.9 Zinc increases the microbial diversity in the intestines10 and similar to butyric acid, it upregulates the expression of tight junction proteins.11
Tight junctions bind the cells lining the gut to create a barrier. The barrier is critical in the proper function of the intestines to absorb nutrients and secreting enzymes. A breakdown in the barrier will lead to a reduction in nutrient absorption as well as lead to leaky gut.
Inclusion of ButiPEARL Z in the diets of swine and poultry can positively impact the intestinal barrier focusing on the tight junctions. By upregulating the tight junctions, ButiPEARL Z can help increase the force exerted between the epithelial cells and minimize permeability, thus reducing the incidence of leaky gut.
ButiPEARL Z inclusion rate is 0.5–1.5lbs for broilers, layers, turkeys and 1.0–3.0lbs for swine, per ton of complete feed. ButiPEARL Z is packaged in 25 kg bags. Store in a cool, dry place not exposed to sunlight to maximize the 18-month shelf-life.
Since earning the prestigious Global Food Safety Initiative (GFSI) recognition at its Des Moines, Iowa, manufacturing facility in February 2013, Kemin Industries has remained a leader in the production of safe, quality ingredients. the recognition reinforces the company's investment in human and financial capital to enhance existing conditions and processes, verifying its products are safe, efficient and effective until they reach the end consumer. Kemin has the FSSC 22000 certification, recognized by GFSI, which is accepted by food manufacturers worldwide.
The Kemin Gut Health Triple Check program helps establish intestinal integrity and protection. Kemin offers products to CLEAN UP contaminants in feed and water prior to animal exposure, BUILD UP intestinal strength and immunity to reduce leaky gut and KNOCK OUT harmful pathogens for healthier and better performing poultry.
ButiPEARL® Z was developed for the BUILD UP category by strengthening the intestinal barrier and immune system to maximize nutrient absorption and inhibit harmful pathogens or toxins.
Comparison of the bioavailability of different zinc sources can help determine if zinc can be utilized by the animal. This study was conducted to determine how much zinc is available in a butyric acid and zinc-combined product.
In order to determine the proper feeding level of butyric acid and zinc for broilers, Kemin conducted a feeding trial to measure the benefits in broiler diets. With increasing levels of butyric acid and zinc, it was determined a 1 pound inclusion to 1 ton of feed provided the best benefit of butyric acid and zinc to broilers.
In this test, it was hypothesized that combining butyric acid and zinc would have beneficial effects towards the intestine, particularly if supplemented during a stress condition like an inflammatory challenge or heat stress. Butyric acid and zinc effects were tested in an in vitro cell culture model to determine if any positive benefits could be detected.
Heat stress can result in muscle damage, oxidative stress and death, but it's possible its most common impact is on the gastrointestinal tract. The study below was done to evaluate the protective effects of an encapsulated source of butyric acid and zinc on swine performance and intestinal integrity during heat stress.
ButiPEARL® Z has been shown to improve growth performance of broilers in previous trial work. The present study evaluated the impact of ButiPEARL Z on performance parameters, gut integrity and meat quality during heat stress in male broiler chickens reared to 47 days of age.
1Peng, L., et al. 2009. Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly via Activation of AMP-Activated Protein Kinase in Caco-2 Cell Monolayers. J. Nutr. 139:1619-1625.
2Ma, X., et al. 2012. Butyrate promotes the recovering of intestinal wound healing through its positive effect on the tight junctions. J. Anim. Sci. 90:266-268.
3Kotunia, A., et al. 2004. Effect of sodium butyrate on the small intestine development in neonatal piglets fed by artificial sow. J. Physiol. Pharmacol. 55:59-68.
4Guilloteau, P., et al. 2012. From the gut to the peripheral tissues: The multiple effects of butyrate. Nutr. Res. Rev. 23:366-384.
5Stefanidou, M., et al. 2006. Zinc: A multipurpose trace element. Arch. Toxicol. 80:1-9.
6Wellinghausen, N., et al. 1998. The significance of zinc for leukocyte biology. J. Leukoc. Biol. 64:571-577.
7McKall, K. A., et al. 2000. Function and Mechanism of Zinc Metalloenzymes. J. Nutr. 130:1437S-1446S.
8Lansdown, A. B. G., et al. 2007. Zinc in wound healing: Theoretical, experimental, and clinical aspects. Wound Rep. Reg. 15:2-16.
9Sahin, K., et al. 2009. Role of dietary zinc in heat-stressed poultry: A review. Poult. Sci. 88:2176-2183.
10Katouli, M., et al. 1999. The effect of zinc oxide supplementation on the stability of the intestinal flora with special reference to composition of coliforms in weaned pigs. J. of Applied Microbiology. 87:564-573.
11Zhang, B., et al. 2012. Zinc prevents Salmonella enterica serovar Typhimurium-induced loss of intestinal mucosal barrier of function in broiler chickens. Avian Pathology. 41:361-367.
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