Tannic Acid Extract & Intestinal Integrity
Tannic Acid Extract (TAE)
Figure 1. Tannic acid molecule3
The astringent activity of tannic acid positively impacts the small intestine. When delivered to the small intestine, tannic acid can contract the mucus membrane. Tannic acid can also constrict the capillaries, which can then prevent leakage.4
Tannic acid may help control oxidative stress and inflammatory response through modulation of pro-inflammatory gene expression, inhibiting inflammatory cytokines and redox balance.5,6,7
The anit-pathogenic benefits of tannic acid are seen by the molecule acting directly on the organism to inactivate it and not allow for the pathogen to grow. Studies also suggest anti-viral activity of tannins by not allowing the virus to attach to cells.8
Effects of Tannic Acid Extract on Intestinal Integrity
Trans-epithelial resistance (TER) is a measuremet of the electrical resistance exerted by the tight junction proteins in the epithelial cell membrane.
Figure 1. Intestinal epithelial cell culture model used to measure TER1
Figure 2. Effect of TAE on intestinal integrity with inflammatory challenge conditions (LPS)2
Tannic acid extract improves intestinal integrity under inflammatory challenge conditions.