ButiPEARL™ Z—Optimal for Gut Health

ButiPEARL™ Z is a feed additive containing two powerful nutrients, butyric acid and zinc oxide, to improve intestinal health and performance in livestock and poultry.  The company’s proprietary MicroPEARLS® spray freezing technology allows for the timely release of these two key nutrients throughout an animal’s gastrointestinal (GI) tract. ButiPEARL Z inclusion rate is .05 to 3 lbs per ton of complete feed and is packaged in 25 kg bags. Store in a cool dry place to maximize shelf life.

Butyric acid and zinc play an important role in key biological processes affecting the health and performance of production animals. Research indicates butyric acid and zinc are necessary to maintain the structural integrity of an animal’s GI tract and key in creating a microflora balance. In addition to the nutritional benefits, encapsulation provides superior handling by reducing the odor associated with butyric acid

Gut Health

The GI tract is a highly complex system including the structural integrity of the intestine, the balance of microflora and the status of the immune system.

Key factors impacting gut health:

  1. Microbiota: a diverse population of microbes contributing to intestinal digestive functions such as influencing epithelial physiology, stimulating intestinal immunity and protecting against pathogens.
  2. Intestinal barrier: a single layer of epithelial cells separating the host from the intestinal lumen and is critical for fluid and electrolyte secretion. It absorbs nutrients and excludes harmful compounds while also being exposed to about 10 trillion microorganisms.
  3. Tight junctions: multi-protein complexes tightly binding epithelial cells together to regulate paracellular permeability. Tight junctions are crucial for the integrity of the epithelial barrier.The dissociation of tight junctions leads to the breakdown of the intestinal barrier, allowing harmful molecules and compounds to pass through. This breakdown results in losses of animal production and efficiency. The loss of the epithelial barrier can result in reduction in nutrient absorption, increase in bacterial translocation, intestinal and systematic inflammation, increased disease and performance loss. 

Internal Environment, Tight Junctions, and Barrier Breakdown

Butyric Acid

Butyric acid is an integral short-chain fatty acid acting as an energy source for epithelial cells, butyric acid improves gut health through development of the intestinal epithelium. Benefits of butyric acid include the upregulation of the expression of tight junction proteins in the intestines1, 2 and increases antioxidant levels to promote healing in the GI tract2. Butyric acid increases epithelial proliferation3 and host defense peptides4 while also reducing inflammation5.

ButiPEARL Z Mode of Action


Zinc is an essential nutrient with a pivotal role in many key biological processes affecting the health and performance of livestock and poultry. Zinc serves as a structural role in DNA replication6 and aids in T-cell development7. It is a cofactor for metabolic enzymes8, wound healing enzymes9 and antioxidants10. Zinc increases the microbial diversity in the intestines11 and similar to butyric acid, it upregulates the expression of tight junction proteins12.

Commitment to Quality and Food Safety

Since earning the prestigious Global Food Safety Initiative (GFSI) recognition at its Des Moines, Iowa, manufacturing facility in February 2013, Kemin Industries remains a leader in the production of safe, quality ingredients. The recognition reinforced the company’s investment in human and financial capital to enhance existing conditions and processes, Kemin has the FSSC 22000 certification, recognized by GFSI, which is accepted by food manufacturers worldwide.

Total Nutrition

Through TOTAL NUTRITION™, Kemin offers a range of nutritional solutions for raising healthy animals. Kemin understands your need to raise healthy livestock and poultry to provide consumers the nutritional and health benefits they are looking for, while also returning a profit. We focus our products and services to help you achieve: safe, healthy, and efficient solutions.





ButiPEARL Z has been shown to improve growth performance of broilers in previous trial work. However, the effect of ButiPEARL Z on heat stressed broiler chicken performance, gut integrity and meat quality has yet to be evaluated. The present study evaluated the impact of ButiPEARL Z on performance parameters, gut integrity and meat quality during heat stress in male broiler chickens reared to 47 days of age. 




1. Peng L, et al. Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly via Activation of AMP-Activated Protein Kinase in Caco-2 Cell Monolayers. 2009. J. Nutr. 139: 1619-1625;

2. Ma X, et al. butyrate promotes the recovering of intestinal wound healing through its positive effect on the tight junctions. J anim Sci, 2012. 90: 266-268;

3. Kotunia A, et al. Effect of sodium butyrate on the small intestine development in neonatal piglets fed by artificial sow. J Physiol Pharmacol. 2004. 55: 59-68;

4. Guilloteau P, et al. From the gut to the peripheral tissues: the multiple effects of butyrate. 2012. Nutr Res Rev. 23:366-384;

5. Guilloteau P, et al. From the gut to the peripheral tissues: the multiple effects of butyrate. 2012. Nutr Res Rev. 23: 366-384;

6. Stefanidou M, et al. Zinc: a multipurpose trace element. 2006. Arch Toxicol 80: 1-9;

7. Wellinghausen N, et al. The significance of zinc for leukocyte biology. 1998. J. Leukoc. Biol. 64: 571-577;

8. McKall, KA, et al. Function and Mechanism of Zing Metalloenzymes. 2000. J. Nutr. 130:1437S-1446S;

9. Lansdown ABG, et al. Zinc in wound healing: Theoretical, experimental, and clinical aspects. 2007. Wound Rep Reg 15: 2-16;

10. Sahin K, et al. Role of dietary zinc in heat-stressed poultry: A review. 2009. Poult. Sci. 88: 2176-2183;

11. Katouli M, et al. The effect of zinc oxide supplementation on the stability of the intestinal flora with special reference to composition of coliforms in weaned pigs. 1999. J of Applied Microbiology. 87: 564-573;

12. Zhang B, et al. Zinc prevents Salmonella enterica serovar Typhimurium-induced loss of intestinal mucosal barrier of function in broiler chickens. 2012. Avian Pathology. 41: 361-367.

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