Butyric Acid – A Foundation For A Healthy Gut

ButiPEARL™ is an encapsulated source of butyric acid manufactured using a proprietary spray freezing process. MicroPEARLS® spray freezing technology allows for the slow release in the GI tract promoting an efficient use of butyric acid in swine and poultry. The encapsulation process greatly reduces the odor typically associated with butyric acid.    

Role of Butyric Acid in Digestion

Butyric acid is one of the short chain fatty acids (SCFA) most efficiently used by the epithelial cells of the gastrointestinal (GI) tract. Butyric acid promotes the growth of tissues lining the GI tract and development of the intestinal epithelium in monogastric animals.1,2

Benefits of Butyric Acid

  • Cellular signaling to enterocytes1
  • Improves tight junctions in the intestines2
  • Increases antioxidant levels to promote healing in the GI tract2
  • Improves intestinal development3
  • Modulates immune response4
  • Reduces inflammation4

Delivering butyric acid at the right place, right time

A fat matrix surrounds the butyric acid ensuring the MicroPEARLS is not digested immediately; it is the delivery system for the active material.

  • Particles of butyric acid salt are embedded in the MicroPEARLS matrix during the manufacturing process. Particles are released in the presence of an aqueous environment, leaving holes to new unexposed particles.
  • Liquid enters through exterior holes into the pearls and contacts the other particles of butyric acid. These particles are then released leaving new holes, as liquid contacts them. In the end, pearls look like empty shells.
  • The released material disassociates into butyric acid and calcium. The butyric acid can be absorbed by the epithelial cells of the intestinal tract. The calcium is also absorbed while the fat matrix is excreted.

Commitment to Quality and Food Safety

Since earning the prestigious Global Food Safety Initiative (GFSI) recognition at its Des Moines, Iowa, manufacturing facility in February 2013, Kemin Industries remains a leader in the production of safe, quality ingredients. The recognition reinforced the company’s investment in human and financial capital to enhance existing conditions and processes, verifying its products are safe, efficient and effective until they reach the end consumer. Kemin has the FSSC 22000:2013 certification, recognized by GFSI, which is accepted by food manufacturers worldwide.

Solutions Driven, Customer Committed

Through TOTAL NUTRITION™, Kemin offers a range of nutritional solutions for raising healthy animals. Kemin understands our customers want to raise healthy livestock and poultry giving consumers the nutritional and health benefits they are looking for, while also returning a profit. Kemin offers products and services to help achieve safe, healthy and efficient solutions for today’s competitive marketplace. 


Kemin encapsulation facility

An encapsulation facility at Kemin


1. Peng L, et al. Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly via Activation of AMP-Activated Protein Kinase in Caco-2 Cell Monolayers. J. Nutr.; Sep 2009; 139: 1619-1625.
2. Ma X, et al. Butyrate promotes the recovering of intestinal wound healing through its positive effect on the tight junctions. J Anim Sci.; Dec 2012; 90 Suppl 4: 266-268.
3. Kotunia A, et al. Effect of sodium butyrate on the small intestine development in neonatal piglets fed [correction of feed] by artificial sow. J Physiol Pharmacol. Jul 2004; 55 Suppl 2:59-68.
4. Guilloteau P, et al. From the gut to the peripheral tissues: the multiple effects of butyrate. Nutr Res Rev. 2010; 23:366–384.

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