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Mode of Action of Antibiotic Growth Promoters (AGPs)

Ideal AGP Alternatives

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What Do We Expect From an AGP Alternative?

Mode of Action of Antibiotic Growth Promoters (AGPs)

  • By reducing the incidence and severity of sub clinical infections (George et al., 1982; Brennan et al., 2003)
  • By reducing microbial use of nutrients (Synder and Wostmann, 1987)
  • By improving absorption of nutrients because of thinning of intestinal wall (Braude et al. 1955; Coates, Davis and Kon, 1955b; Moran and McGinnis, 1967; Franti et al, 1972; Stutz and Johnson, 1976)
  • By reducing the amount of growth depressing metabolites produced by gram +ve bacteria (Feighner and Dashkevicz, 1987; Knarreborg et al., 2004)
  • By changing morphology in the gut wall and induce immune reactions (Humphrey and Klasing., 2003 Teirlynck et al., 2009)
  • By inhibiting the production and excretion of cytokines by immune cells (macrophages), - Antiinflammatory effect (Niewold, 2007)

Criteria for Alternatives to Antibiotics (AGPs)

  • Prevent pathogens - Clostridium perfringens
  • Positive event on commensals
  • Anti-inflammatory effect and intestinal wall vitality
  • Compatibility with commonly used feed additives and feed pellet stability
  • No resistance issues and no withdrawal periods
  • Improvement in animal performances - FCR body weight, and low mortality

Producing Chicken and Swine Without In-Feed Antibiotics Requires a Combination of Different Strategies

  • Management strategies
  • Nutritional strategies
  • Health management
  • Appropriate alternatives in feed

T.L.J.Lawrence. Growth in Animals: Studies in the Agricultural and Food Sciences. An update on alternatives to antimicrobial growth promoters for broilers Gerard Huyghebaert. The Veterinary Journal 187 (2011) 182-188
T.A. Niewold, The Nonantibiotic Anti-Inflammatory Effect of Antimicrobial Growth Promotors, the Real Mode of Action? A Hypothesis. 2007 Poultry Science 86:605-609 Shutterstock_393655342 - Shutterstock__18784985