TOXFIN™ – An Effective Tool for Mycotoxin Management in Swine Production
Whether it concerns swine or other species, mycotoxin control is essential for health and performance, as mycotoxins are present in almost all agricultural ingredients.
TOXFIN™ is a family of mycotoxin binders consisting of unique activated adsorbents that bind the relevant mycotoxins like Aflatoxin (e.g. Bentonite 1m558 following European regulation 1060/2013), zearalenone, ochratoxin, T-2, fumonisin along the gastrointestinal tract, reducing mycotoxin bio-availability and promoting their excretion from the pig’s body.
Importance of Mycotoxin Control Programs
Mycotoxins are secondary metabolites produced by fungi or moulds that display widely-varying toxic properties (carcinogenic, immunosuppressive, hepatotoxic, nephrotoxic, neurotoxic, etc.) in humans and animals. The risk of mycotoxins entering the feed chain is almost unavoidable, as they contaminate almost all agricultural ingredients, consequently affecting swine health and performance. For example, the presence of zearalenone and deoxynivalenol in sow and piglets feed are causing specific symptoms like swollen vulvas and vomiting respectively.
To partner with customers and to help maintain their feed quality and safety, Kemin created Customer Laboratory Services (CLS). CLS is translating customer needs into innovative tools going from routine mycotoxin screening to mycotoxin binding efficacy tests. A mycotoxin analysis on different raw materials and finished feeds provides fundamental information, allowing the correct implementation of the most cost-effective control actions. By taking preventative measures and using the right mycotoxin adsorbent you can protect your business and animals from the negative effects of mycotoxins. Choosing the right mycotoxin adsorbent can be a burden, but doesn’t need to be one. Their efficacy can be easily evaluated by an in vitro mycotoxin adsorption test, as a first screening method.
TOXFIN - When in vitro Tests are Confirmed by in vivo Toxicokinetic Studies
A first screening method to evaluate the binding efficacy of a mycotoxin binder is an in vitro adsorption test. A protocol for a mycotoxin adsorption test was developed by Kemin’s Customer Lab Services (CLS) to screen the efficacy of adsorbents guaranteeing the efficacy of TOXFIN. According to the European Food Safety Authority, the efficacy of mycotoxin-detoxifying agents should also be investigated based on in vivo trials, measuring specific parameters such as the toxin or a metabolite of the toxin in plasma or other tissues of the animal. Therefore, toxicokinetic studies with TOXFIN were performed in piglets in addition to the in vitro adsorption tests to confirm that TOXFIN effectively adsorbs the mycotoxins in the gastro-intestinal tract preventing the absorption of the toxins into the bloodstream, negatively affecting animal health.
TOXFIN Product Range
TOXFIN is a unique family of mycotoxin binders formulated with a carefully selected blend of activated clays and non-digestible organic ingredients that bind the relevant mycotoxins (Aflatoxin, ochratoxin, T-2, fumonisins …) along the gastrointestinal tract, thereby reducing mycotoxin absorption into the animal's bloodstream and promoting their excretion from the animal’s body. Only a perfect combination of activated binding agents can meet the essential requirements for a broad-spectrum mycotoxin binder since no single adsorbent is effective against all relevant mycotoxins. Supported by a sound multi-level research approach combining in vitro and in vivo studies, TOXFIN product range has shown to be effective under field conditions keeping animals healthy and performant in cases of mycotoxin exposure.
- Multi-mycotoxin binder specially designed to bind and promote the excretion of ingested mycotoxins. Includes bentonite (1m558) fulfilling the European Regulation 1060/2013 as an aflatoxin B1 binder.
- Potentiated broad spectrum mycotoxin binder specially designed to bind and promote the excretion of ingested mycotoxins. TOXFIN™ XL includes bentonite (1m558) (fulfilling the European Regulation 1060/2013 as an aflatoxin B1 binder) and an innovative organic compound. This product is specially designed for a high binding affinity for Zearalenone, Ochratoxin, fumonisins and T-2/HT-2 toxins. Suited for piglets, growing pigs, sows and gilts.
- Broad spectrum mycotoxin binder specially designed to bind and promote the excretion of ingested mycotoxins and is the solution for zearalenone sensitive animals. TOXFIN™ Supreme includes a unique sepiolite with a proven broad-spectrum activity and high level of an innovative patented organic compound. This special formula has broad binding activity for all mycotoxins with a superior activity versus Zearalenone. Especially suited for mycotoxin (zearalenone) control in sensitive species such as breeding animals (sows and gilts) and piglets.
Dosage recommendations are depending on the mycotoxin challenge, animal health status, age and product. All TOXFIN products are manufactured in Europe, without the use of GMO and available in dry powder packed in 25 kg bags and 1000kg big bags.
It is advised to contact the Kemin technical team for more information about the TOXFIN product range.