Unique scientific proof for the sustained release of ButiPEARL

Why do we need to encapsulate?

Butyric acid is known to improve intestinal integrity and therefore supports a healthy and optimal growth performance.  Despite its benefits, butyric acid has a very strong (pungent) odor and is known to be hygroscopic in its dry form, making it very difficult to work with in premixes or feed production.  Additionally, butyric acid is rapidly absorbed by the mucosa cells of the gastrointestinal tract of animals. Encapsulation reduces the bad smell, avoids interaction with other ingredients in premixes and feed making more flowable and easy to handle, and delivers the active ingredient to the small and large intestine where it can perform at its best.

MicroPEARLS Technology- What is this about?

MicroPEARLS technology results in the formation of PEARLS where butyrate salt molecules end up embedded within a fat matrix. Just like a chocolate chip cookie contains pieces of chocolate inside, outside, and in between the dough; a PEARL contains butyrate molecules exposed on the surface of the PEARL and many others resting embedded within the matrix.

Research by USDA scientists (Smith et al. 2012) confirmed that ButiPEARL has a sustained release of calcium butyrate along the gastrointestinal tract.


Encapsulation: butyric acid, calcium butyrate, MicroPEARLS technology

This study with radiolabeled calcium butyrate unprotected and protected with the MicroPEARL technology demonstrated the following:

  • MicroPEARLS encapsulation does not affect overall butyrate availability
  • The availability of butyrate in the intestinal lumen for utilization by the epithelial cells is greater with ButiPEARL due to the MicroPEARLS technology (Figure 2).
  • MicroPEARLS encapsulation delays absorption of butyrate, allowing the butyrate to reach the small intestine and the hindgut. Comparison of butyric acid recovery from radiolabelled ButiPEARL versus an uprotected source of butyric acid.

MicroPEARLS technology

Data are the mean ± SEM of 20 birds Points marked with asterisks differ (∗∗, P < 0.01; ∗∗∗, P < 0.001) between protected and unprotected at indicated time points.
Figure 1. Taken from Smith et al., 2012. Release of [14C] CO2 in birds orally doses with unprotected (circles)  and protected (squares) calcium [1-14C] butyrate.

 

Clearly, the MicroPEARLS encapsulation technology makes a difference.

 

Reference: Smith J., Barri A., Herges G., Hahn J, Yersin G. A., and Jourdan Alissa. In Vitro Dissolution and In Vivo Absorption of Calcium [1-14C] Butyrate in Free or Protected forms. Journal of Agricultural Food Chemistry 2012.

 

 

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