Aleta™ – Immune Modulator for Optimal Animal Health

Healthy animals are more likely to provide higher production efficiency and economic profitability. Whether it concerns ruminants, swine, poultry or aquaculture, immune support, disease resistance and overall (intestinal) health improvement can have far reaching benefits in animal production.

Aleta™ is a pure and highly bioavailable algae-based solution which provides a high and consistent concentration of Beta-(1,3)-Glucan to improve immunity and animal performance. Serving as an immunostimulant or immune booster in animals, Aleta can be a cost-effective in-feed solution to manage stress induced immunosuppression, and to support animals in antibiotic growth promoter (AGP) removal programs.

Advantages of Aleta

  • Improves the animal’s natural defense system
  • Helps animals resist stressful conditions: heat, cold, vaccinations
  • Helps animals resist challenging conditions
  • Modulates inflammation
  • Improves production performance parameters:
    • Feed conversion ratio
    • Body weight
    • Reduces mortality 
  • Supports animals in antibiotic growth promoter (AGP) replacement programs
  • Supports animals in antibiotic reduction programs
  • Supports general gut health

Beta-(1,3)-Glucan from Aleta is a Highly Bioavailable Immunomodulator

Beta-Glucans are polysaccharides, naturally occurring as a structural component of yeasts, fungi, certain bacteria or in cereals or as a storage carbohydrate in specific algae. Beta-Glucans are known since several years for their immunomodulatory effects. Unlike yeast products – which contain only 5 to 25 percent Beta-Glucan and require extraction from an indigestible cell wall – Aleta is produced from Euglena gracilis, a unique alga which contains more than 50 percent Beta-Glucan. These algal cells are highly digestible, making Aleta’s Beta-(1,3)-Glucan bioavailable without extraction.

The phase contrast image of Euglena gracilis clearly shows the carbohydrate storage molecules present in the cytoplasm, containing Beta-(1,3)-Glucan. 

 

The Beta Glucan structure present in Euglena gracilis: Beta-(1,3)-Glucan, a chain of glucose molecules connected by β-glycosidic bonds between #1 and #3 carbons.

Aleta Provides Proactive Immune Modulation

To minimize disease incidence in food-producing animals, producers often rely on farm management, disease management, vaccination and treatment. Despite improvements in management practices and availability of vaccines against infectious diseases in food-producing animals, there are still outbreaks that cost the animal husbandry industry billions of dollars of economic losses.

Key examples of modern disease outbreaks in food-producing animals:

  • Necrotic enteritis and coccidiosis, two important intestinal disorders in poultry, cost the broiler industry billions of dollars worldwide due to increased mortality and growth reduction.  
  • E. coli induced diarrhea cost pig farmers in the UK up to £3.7 million each year, losses per pig could be between £4 and £10. 2

In addition to production losses in livestock systems, some of the pathogens present in food-producing animals are zoonotic agents. The presence of such agents implicates also a huge socioeconomic impact for a region. Salmonellosis is one important example, as estimates say the average cost per case of human salmonellosis in the European Union is more than 1000€ or a total cost of around 132 612 837€ for the EU.1 Controlling pathogens in livestock is highly important for both health and economic reasons.

As an immunomodulator in animals, Aleta can help to avoid these types of losses. Aleta heightens its immunologic capabilities when an animal may be exposed to one or more pathogens or be compromised immunologically.

Aleta - Use During Stressful and Challenging Conditions

Aleta can be used during stressful and challenging conditions in an animal’s life. Challenging conditions need to be well managed to guarantee a good health and overall performance. Some critical periods during an animal’s lifetime are clearly defined:

  • Young animals, especially during the postnatal period when the immune system may not be fully developed. Bridging the immunity gap – when the maternal immunity is gone and the newborn‘s immune system is not well developed yet – is crucial in young animals.
  • During the weaning period. Animals are exposed to different stress factors during this event: they are taken away from their mother and are receiving a different feed. Both events are challenging for the intestinal health and the immune system.
  • High production periods such as lactation and gestation. These periods require high energy and nutrient availability, and consequently have a negative impact on immune function.
  • Intense vaccination programs which require an optimal function of the immune system to guarantee a good response and future protection against diseases.
  • Stress and pathogen (viruses, bacteria or protozoa) induced immunosuppression.
  • Antibiotic reduction and AGP removal programs. Among proper farm management and improved biosecurity, novel feed additives are helpful in reducing prophylactic as well as therapeutic use of antibiotics.

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