ZeaONE® - A Natural (RR) Dietary Zeaxanthin Ingredient for Eye Health

(RR) Dietary zeaxanthin, like lutein, is naturally deposited in the eyes to form macular pigment, which keeps our eyes functioning their best. Zeaxanthin is found naturally in common vegetables like corn, squash and peppers. But, most Americans only get 10% of the recommended amount.

ZeaONE Zeaxanthin is a supplement ingredient for eye health that's naturally-sourced from marigold flowers. Together, zeaxanthin and lutein help filter damaging blue light and enhance quality of vision. 22-25 When formulated into a supplement with FloraGLO Lutein, ZeaONE Zeaxanthin:

  • Helps eyes recover more quickly from intense light10,11
  • Enhances quality of vision, even in people with 20/20 vision22-25
  • Filters excess blue light12,13
  • Helps reduce the progression of advanced macular degeneration (AMD)

The importance of zeaxanthin supplementation

Current research recommends at least 10 mg of lutein and 2 mg of zeaxanthin daily to keep eyes healthy and performing their best.  Since the human body doesn't produce these carotenoids for vision, it's important to consume these nutrients from foods or dietary supplements. Most individuals aren't consuming enough fruits and vegetables that contain lutein and zeaxanthin. In fact, most people only get 1-2 mg each day - far below the amounts proven to be beneficial for eye health.15

Many formulations don't provide natural, free-form (RR) dietary zeaxanthin

ZeaONE is free-form zeaxanthin naturally sourced from marigold flowers. It's important to realize that not all zeaxanthin ingredients are equal. And the difference between them is significant...

Our body prefers free-form zeaxanthin

Through diet and supplementation, zeaxanthin is absorbed and selectively deposited in the eye, brain, skin and even breast milk.13-12 Research has shown that only the free form of zeaxanthin is found in these tissues and is directly absorbed into the bloodstream delivering all important intended benefits, while zeaxanthin esters or (RS) meso-zeaxanthin is not.13


Beware of (RS) meso-zeaxanthin: Demand the real thing

Not all zeaxanthin is the same. Some products are misrepresented as containing (RR) dietary zeaxanthin, when in fact, they are purposefully formulated to contain a zeaxanthin stereoisomer: 3R, 3’S-meso-zeaxanthin. (RS) Meso-zeaxanthin, sometimes confusingly referenced on labeling as “zeaxanthin isomers,” is quite different than (RR) dietary zeaxanthin and is not a suitable replacement.

(RS) Meso-zeaxanthin is not found naturally in the diet

Our eyes are naturally protected by macular pigment. The body absorbs lutein and zeaxanthin through our diet and selectively deposits them into macular pigment. Some sources argue that (RS) meso-zeaxanthin is also found in macular pigment, but this is a result of the body naturally converting lutein into (RS) meso-zeaxanthin via an enzymatic process that occurs within the structures of the eye.19-21

Nature has given us abundant sources of zeaxanthin like common fruits and vegetables. (RS) Meso-zeaxanthin; however, is not found naturally in any conventional dietary source.

The science behind (RS) meso-zeaxanthin is not developed 

Evidence to support the use of (RS) meso-zeaxanthin is lacking compared to the overwhelming support in the published literature linking zeaxanthin and lutein supplementation to improved eye health.14

To date, there has been no published research on the eye health or otherwise, in animal models or human clinicals using supplemental meso-zeaxanthin alone without the presence of zeaxanthin and lutein. This makes it impossible to attribute any effects to (RS) meso-zeaxanthin alone.

Additionally, research shows that supplemental (RS) meso-zeaxanthin may compete with zeaxanthin and lutein absorption, hindering them from reaching the macula where they are critical for maintaining healthy eyes and protecting our vision as we age.15-17

Choose free-form zeaxanthin

Hundreds of studies have shown that zeaxanthin and lutein help keep our eyes healthy, improve visual performance and maintain eye health as we age. In fact, the benefits of zeaxanthin and lutein supplementation are supported by 30 years of clinical studies.5-23

ZeaONE is a safe, trusted ingredient for eye health

ZeaONE Zeaxanthin is distributed by DSM Nutritional Products as OPTISHARP® Natural. Kemin manufactures ZeaONE in accordance with the U.S. FDA Good Manufacturing Process (GMPs) facility and delivers it through a carefully controlled supply chain. ZeaONE has received GRAS status from the FDA, making it the first (RR) dietary zeaxanthin from marigold flowers and the first brand to specifically evaluate the safety of ZeaONE zeaxanthin in pregnant women.

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References available upon request.

OPTISHARP® Natural is a Registered Trademark of DSM Nutritional Products Ltd.

OPTISHARP® Natural is made with patented ZeaOne(R) from KEMIN. ZeaOne is a [registered] trademark of KEMIN Industries, Inc. Licensed under U.S. Patent Nos. 6,784,351, 7,575,766 and 7,033,622.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Certain statements may not be applicable in all geographical regions. Product labeling and associated claims may differ based upon government requirements.

* Based on a biannual PubMed search analysis. Counts only include studies using FloraGLO brand Lutein. Numbers are considerably higher when other sources of dietary lutein and zeaxanthin are considered. (Kemin Foods L.C. Internal Memorandum based on PubMed Search 2015).

† Refers to trials where there were not individual investigators in common among all trials

+ JECFA: Joint Expert Committee on Food Additives