CLOSTAT™ -  A Natural Defense Against Costly Pathogens

Intestinal health issues in poultry and livestock are a constant concern for producers around the world.

CLOSTAT is a non-species specific animal feed ingredient that can help improve gut health and the overall efficiency of poultry and livestock.

The active microbial in CLOSTAT, Bacillus subtilus PB6, acts as a natural defense mechanism against pathogenic strains of bacteria without causing antibiotic resistance or residue issues.

Key Benefits of CLOSTAT: 

  • Maintains a balanced microbial ecosystem and gastrointestinal tract1
  • Produces distinctive biocides with specific activity against pathogenic strains of Clostridum perfringens2
  • Prevents necrotic enteritis and bacterial enteritis and dysbiosis
  • Does not create antibiotic resistance or residue concerns1
  • Acts as a replacement for antimicrobial growth promoters for improved gut health in broiler birds1
  • Supports nutrient absorption through optimal gut health
  • Reduces potential medication costs due to preventive gut health management
  • Improves profit margin through reduced mortalities, improved litter quality and fewer rejections at slaughterhouse
  • Plus, CLOSTAT can be used on organic farms.

Watch the video below to learn the mechanism of action behind CLOSTAT.


Beyond the key benefits and well-studied mechanism of action, CLOSTAT offers the following formulation benefits: 

  • Fully stable in feeds and premixes3
  • Heat stable upon pelleting3
  • Compatible with nearly all organic acids3
  • Compatible with nearly all anticoccidials3

Have a question or need to discuss a specific situation? Contact us at 011 206 8000.


1. Jayaraman. S.,Thangavel. G., Kurian. H. & Mani. R., Bacillus subtillus PB6 improves intestinal health of broiler chickens challenged with Clostridium pefringens - induced necrotic enteritis. 2013 Poulty Science 92 :370-374.

2. Alex Yeow-Lim Teo & Hi-Meng Tan. Inhibition of Clostridium pefringens by a Novel Strain of Bacillus subtillis Isolated from the Gastrointestinal Tracts of Healthy Chickens. AEM. 71.8.4185-4190.2005.

3. Kemin data on file.

Certain statements may not be applicable in all geographical regions. Product labeling and associated claims may differ based upon regulatory requirements. All claims are supported by scientific and field data.

CLOSTAT™ Farm Tools for Africa Markets

It is important to check the droppings around the drinkers on a daily basis for consistency. If changes are observed, call your veterinarian for expert advice.

Avian Droppings reveal important information for the poultry producer and are a good indicator of the health status of the bird. Experience is necessary in order to monitor the health of the flock via observing changes in fecal and cecal droppings on a daily basis.

Daily Disease Prevention

Close scrutiny of the droppings on a daily basis is the best available method to prevent disease. This monitoring system allows the producer to identify the very first signs of an altered health balance. Taking an action at an early stage, promotes the control of disorders before they have time to become a problem.

There are different types of abnormal droppings:

  • Green (NDV, AI)
  • White (IBD, BWD)
  • Yellow (Parvovirus, Fowl Cholera, Spirochetosis)
  • With Orange mucus/sloughed mucosa (Coccidiosis, Necrotic enteritis, Reovirus)
  • Caramel or foamy (Necrotic enteritis)
  • Red / Bloody (Coccidiosis- Eimeria tenella-, Campylobacteriosis)

What to look for:

  • Increased size or volume
  • Loss of firmness / consistency
  • Becomes oily, bulky
  • Changes in color
  • Watery
  • Presence of undigested feed
  • Changes in smell

Any of these changes can be caused by stress, certain feed, or can be a sign of disease.

What is Diarrhea?

Diarrhea is when the fecal material is not holding its tubular shape. Instead its consistency is loose and more like the consistency of pudding.

There are different types of diarrhea

  • Osmotic
  • Secretory
  • Exudative

Kemin offers natural strategies to maintain a healthy digestive system. CloSTAT™ is a patented active microbial which has demonstrated its efficacy in reducing the incidence of bacterial enteritis, sub-clinical, and clinical necrotic enteritis through the control of pathogenic strains of Clostridium spp. proliferation.

Certain statements may not be applicable in all geographical regions. Product labeling and associated claims may differ based upon regulatory requirements.