ButiPEARL Z - Optimal Delivery of Butyric Acid and Zinc Benefits for Gut Health

ButiPEARL Z is a feed additive containing two powerful nutrients, zinc butyrate, to improve intestinal health and performance in livestock and poultry. The company's proprietary MicroPEARLS® spray freezing technology allows for the timely release of these two key nutrients throughout an animal's gastrointestinal (GI) tract.

Butyric acid and zinc play an important role in key biological processes affecting the health and performance of production animals. Research indicates butyric acid and zinc are necessary to maintain the structural integrity of an animal's GI tract and key in creating a microflora balance. In addition to the nutritional benefits, encapsulation provides superior handling by reducing the odor associate with butyric acid.

Butyric Acid

Butyric acid is an integral short-chain fatty acid acting as an energy source for epithelial cells. Butyric acid improves gut health through development of the intestinal epithelium. Benefits of butyric acid for broilers and swine include the upregulation of the expression of tight junction proteins in the intestines1,2 and increases antioxidant levels to promote healing in the GI tract.2 Butyric acid increases epithelial proliferation3 and host defense peptides,4 while also reducing inflammation.4


Zinc benefits swine, cattle and poultry as an essential nutrient with a pivotal role in many key biological processes affecting the health and performance of livestock. Zinc serves as a structural role in DNA replication5 and aids in T-cell development.6 It is a cofactor for metabolic enzymes,7 wound healing enzymes8 and antioxidants.9 Zinc increases the microbial diversity in the intestines10 and similar to butyric acid, it upregulates the expression of tight junction proteins.11

Encapsulating butyric acid and zinc together provides synergistic benefits for livestock and poultry. The butyric acid and zinc combination is unique in animal health and positively impacts the intestinal barrier for swine, broilers, layers, turkeys and equine.

ButiPEARL Z inclusion rate is 0.22 to 1.35 kg per ton of complete feed and is packaged in 25 kg bags. Store in a cool, dry place to maximize shelf-life.



Determination of the Relative Bioavailability for Zinc Butyrate as Compared to Zinc Sulfate

Comparison of the bioavailability of different zinc sources can help determine if zinc can be utilized by the animal. This study was conducted to determine how much zinc is available in a zinc butyrate-combined product. For more information, download the PDF.

Effects of Feeding Increasing Levels of an Encapsulated Source of Zinc Butyrate to Broiler Diets

In order to determine the proper feeding level of zinc butyrate for broilers, Kemin conducted a feeding trial to measure the benefits in broiler diets. With increasing levels of zinc butyrate, it was determined a 0.45 kg inclusion to 1 ton of feed provided the best benefit of butyric acid and zinc to broilers. Download the PDF to read more.

Evaluation of the Protective Effects of Zinc Butyrate on Swine Intestinal Epithelial Cells Under Inflammatory Challenge and Heat Stress Conditions

In this test, it was hypothesized that combining butyric acid and zinc would have beneficial effects towards the intestine, particularly if supplemented during a stress condition like an inflammatory challenge or heat stress. Butyric acid and zinc effects were tested in an in vitro cell culture model to determine if any positive benefits could be detected. To read more about this trial, download the PDF.

The Protective Effects of Zinc Butyrate on Grower Swine Under Heat Stress Conditions

Heat stress can result in muscle damage, oxidative stress and death, but possible its most common impact is on the gastrointestinal tract. The combination of heat stress and decreased feed intake associated with stress can result in severe losses. The study below was done to evaluate the protective effects of an encapsulated source of zinc butyrate (ButiPEARL Z) on swine performance and intestinal integrity during heat stress. For more information on ButiPEARL Z and heat stress, download this PDF.

The Effect of Encapsulated Zinc Butyrate on Performance, Gut Integrity and Meat Quality in Male Broiler Chickens

ButiPEARL Z has been shown to improve growth performance of broilers in previous trial work. However, the effect of ButiPEARL Z on heat stressed broiler chicken performance, gut integrity and meat quality has yet to be evaluated. The present study evaluated the impact of ButiPEARL Z on performance parameters, gut integrity and meat quality during heat stress in male broiler chickens reared to 47 days of age. Download the PDF for more information.

Commitment to Quality and Food Safety 

Since earning the prestigious Global Food Safety Initiative (GFSI) recognition at its Des Moines, Iowa, manufacturing facility in February 2013, Kemin Industries has remained a leader in the production of safe, quality ingredients. The recognition reinforced the company's investment in human and financial capital to enhance existing conditions and processes. Kemin also has the FSSC 22000 certification, recognized by GFSI, which is accepted by food manufacturers worldwide. 



1Peng, L., et al. 2009. Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly via Activation of AMP-Activated Protein Kinase in Caco-2 Cell Monolayers. J. Nutr. 139:1619-1625.

2Ma, X., et al. 2012. Butyrate promotes the recovering of intestinal wound healing through its positive effect on the tight junctions. J. Anim. Sci. 90:266-268.

3Kotunia, A., et al. 2004. Effect of sodium butyrate on the small intestine development in neonatal piglets fed by artificial sow. J. Physiol. Pharmacol. 55:59-68.

4Guilloteau, P., et al. 2012. From the gut to the peripheral tissues: The multiple effects of butyrate. Nutr. Res. Rev. 23:366-384.

5Stefanidou, M., et al. 2006. Zinc: A multipurpose trace element. Arch. Toxicol. 80:1-9.

6Wellinghausen, N., et al. 1998. The significance of zinc for leukocyte biology. J. Leukoc. Biol. 64:571-577.

7McKall, K. A., et al. 2000. Function and Mechanism of Zinc Metalloenzymes. J. Nutr. 130:1437S-1446S.

8Lansdown, A. B. G., et al. 2007. Zinc in wound healing: Theoretical, experimental, and clinical aspects. Wound Rep. Reg. 15:2-16.

9Sahin, K., et al. 2009. Role of dietary zinc in heat-stressed poultry: A review. Poult. Sci. 88:2176-2183.

10Katouli, M., et al. 1999. The effect of zinc oxide supplementation on the stability of the intestinal flora with special reference to composition of coliforms in weaned pigs. J. of Applied Microbiology. 87:564-573.

11Zhang, B., et al. 2012. Zinc prevents Salmonella enterica serovar Typhimurium-induced loss of intestinal mucosal barrier of function in broiler chickens. Avian Pathology. 41:361-367.